SML2083
[Ala13]-Apelin-13 trifluoroacetate salt
≥96% (HPLC)
別名:
(F13A)apelin-13, Alanine apelin-13, Apelin-13(F13A), Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala TFA, L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-alanine TFA, QRPRLSHKGPMPA TFA, [Ala-13] apelin-13
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この商品について
実験式（ヒル表記法）:
C63H107N23O16S · xC2HF3O2
CAS番号:
分子量:
1474.73 (free base basis)
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥96% (HPLC)
Form:
powder
assay
≥96% (HPLC)
form
powder
color
white to beige
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
(Ala13)-Apelin-13 corresponds to Apelin-13 with a Phe-to-Ala substitution at the C-terminus (F13A) and functions as an antagonist against apelin-dependent APJ functions both in cultures and in animal studies in vivo.
Apelin-13 with a Phe-to-Ala substitution at the C-terminus (F13A) and functions as an antagonist against apelin-dependent APJ functions.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
SML2083-1MG: + SML2083-5MG: + SML2083-BULK: + SML2083-VAR:
jan
Mehmet Bülbül et al.
American journal of physiology. Gastrointestinal and liver physiology, 310(4), G249-G261 (2015-12-19)
Apelin, an endogenous ligand for APJ receptor, has been reported to be upregulated in paraventricular nucleus (PVN) following stress. Central apelin is known to stimulate release of corticotropin-releasing factor (CRF) via APJ receptor. We tested the hypothesis that stress-induced gastrointestinal
İlknur Birsen et al.
The journal of physiological sciences : JPS, 67(3), 373-385 (2016-07-03)
The objective of this study was to explore the role of apelin in the healing of gastric lesions induced by stress. Male Wistar rats were exposed to water immersion and restraint stress (WIRS) for 6 h with or without the apelin
Xue Han et al.
Atherosclerosis, 244, 1-8 (2015-11-19)
Vascular calcification (VC) is closely related to cardiovascular events in chronic kidney disease (CKD). Apelin has emerged as a potent regulator of cardiovascular function, but its role in VC during CKD remains unknown. We determined whether apelin plays a role
Frédéric Adam et al.
Blood, 127(7), 908-920 (2015-12-05)
Apelin peptide and its receptor APJ are directly implicated in various physiological processes ranging from cardiovascular homeostasis to immune signaling. Here, we show that apelin is a key player in hemostasis with an ability to inhibit thrombin- and collagen-mediated platelet
Dennis K Lee et al.
Endocrinology, 146(1), 231-236 (2004-10-16)
The apelin peptide is the endogenous ligand for the apelin G protein-coupled receptor. The distribution of the apelin peptides and receptor are widespread in the central nervous system and periphery, with reported roles in the hypothalamic-pituitary-adrenal axis, blood pressure regulation
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