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ABT317 Anti-Matriptase-2/TMPRSS6 Antibody

Anti-Matriptase-2/TMPRSS6 Antibody is an antibody against Matriptase-2/TMPRSS6 for use in western blotting & IHC.

Anti-Matriptase-2/TMPRSS6 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: TMPRSS6 UniProt Number: Q8IU80
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ABT317
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABT317
      DescriptionAnti-Matriptase-2/TMPRSS6 Antibody
      Alternate Names
      • Transmembrane protease serine 6
      • Matriptase-2
      Background InformationMatriptase-2/TMPRSS6, also known as Transmembrane protease serine 6, and encoded by the gene TMPRSS6, is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen and appears to play an important role in matrix remodeling in the liver. Matriptase-2/TMPRSS6 also plays an important role in iron homeostasis and interacts with the iron homeostasis protein Hepcidin. Maintaining the body’s levels of iron within precise boundaries is essential for normal physiological function. Alterations of these levels below or above the healthy limit lead to a systemic deficiency or overload in iron. Matriptase-2/TMPRSS6 is a proteolytic regulator of iron homeostasis. Matriptase-2/TMPRSS6 is expressed only in the liver in normal tissues and undergoes proteolytic processing to yield two activated chains that are shed one intracellularly and one extracellularly. Mutations in Matriptase-2/TMPRSS6 gene give rise to iron deficiency anemia.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Matriptase-2/TMPRSS6 Antibody is an antibody against Matriptase-2/TMPRSS6 for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Matriptase-2/TMPRSS6 in human liver and mouse liver tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Matriptase-2/TMPRSS6 near the C-terminal.
      EpitopeNear C-terminal
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TMPRSS6
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~52 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MCF-7 cell lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Matriptase-2/TMPRSS6 in 10 µg of MCF-7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABT317 04053252958212

      Documentation

      Anti-Matriptase-2/TMPRSS6 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Matriptase-2/TMPRSS6 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Matriptase-2/TMPRSS6 - Q2388152 Q2388152
      Anti-Matriptase-2/TMPRSS6 - 3267943 3267943
      Anti-Matriptase-2/TMPRSS6 - 3385860 3385860
      Anti-Matriptase-2/TMPRSS6 - 3750159 3750159
      Anti-Matriptase-2/TMPRSS6 - 3862695 3862695
      Anti-Matriptase-2/TMPRSS6 -2747993 2747993
      Anti-Matriptase-2/TMPRSS6 -2851769 2851769
      Anti-Matriptase-2/TMPRSS6 -2854630 2854630
      Anti-Matriptase-2/TMPRSS6 -2891890 2891890
      Anti-Matriptase-2/TMPRSS6 Polyclonal Antibody 2951427
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