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AB1580-I Anti-Mu Opioid Receptor Antibody

Detect Opioid Receptor using this rabbit polyclonal antibody, Anti-Mu Opioid Receptor Antibody validated for use in western blotting & IHC (Paraffin).

Anti-Mu Opioid Receptor Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: OPRM1, MOR1 UniProt Number: P35372
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AB1580-I
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB1580-I
      ReplacesAB1580
      DescriptionAnti-Mu Opioid Receptor Antibody
      Alternate Names
      • Mu-type opioid receptor
      • M-OR-1
      • MOR-1
      • Mu opiate receptor
      • Mu opioid receptor
      • MOP
      • hMOP
      • Anti-Opioid Receptor μ
      Background InformationMu Opioid Receptor (MOP), also called Mu-type opioid receptor (MOR-1), is a receptor for natural and synthetic opioids such as beta-endorphin, endomorphin, morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. MOP functions as a class A G-protein coupled receptor (GPCR), but its down-regulation pathways vary with the agonist and may or may not be independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling, as opposed to synthetic ligands, like morphine, that trigger only low desensitization and endocytosis. Hetero-oligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. MOP is expressed in the brain and is involved in neurogenesis. MOP is the main physiological target for most clinically important opioid analgesics.
      References
      Product Information
      FormatAffinity Purified
      Control
      • SH-SY5Y cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Opioid Receptor using this rabbit polyclonal antibody, Anti-Mu Opioid Receptor Antibody validated for use in western blotting & IHC (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000-4,000 dilution from a representative lot detected Mu Opioid Receptor in human cerebellum, mouse hippocampus, mouse midbrain, and rat midbrain tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human Mu Opioid Receptor.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the C-terminus of Mu Opioid Receptor. This antibody will recognize isoform 1 (45 kDa), isform 10 (55 kDa), isoform 12 (34 kDa), and isoform 13 (36 kDa).
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with Human and Mouse. Predicted to react with Rat, Porcine, and Bovine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OPRM1
      • MOR1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~70 kDa observed. The calculated molecular weight is 45 kDa, however Opioid Receptor mu has been shown as a ~70-90 kDa band in western blots (Ferrer-Alcon, M., et al. (2004). Molecular Brain Research. 121(1-2):114-122).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SH-SY5Y cell lysate.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected Mu Opioid Receptor in 10 µg of SH-SY5Y cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB1580-I 04053252906664

      Documentation

      Anti-Mu Opioid Receptor Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Mu Opioid Receptor Antibody Certificates of Analysis

      TitleLot Number
      Anti-Mu Opioid Receptor - 3209145 3209145
      Anti-Mu Opioid Receptor - 3323042 3323042
      Anti-Mu Opioid Receptor - 3609983 3609983
      Anti-Mu Opioid Receptor - 3944869 3944869
      Anti-Mu Opioid Receptor - 4186080 4186080
      Anti-Mu Opioid Receptor - Q2187981 Q2187981
      Anti-Mu Opioid Receptor -2555310 2555310
      Anti-Mu Opioid Receptor -2641704 2641704
      Anti-Mu Opioid Receptor -2687788 2687788
      Anti-Mu Opioid Receptor -2736410 2736410
      Show more

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies