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ABE602 Anti-SATB1 Antibody

Detect Special AT-rich sequence-binding protein 1 using this rabbit polyclonal antibody, Anti-SATB1 Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.

Anti-SATB1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: SATB1 UniProt Number: Q01826
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ABE602
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P), IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE602
      DescriptionAnti-SATB1 Antibody
      Alternate Names
      • DNA-binding protein SATB1
      • Special AT-rich sequence-binding protein 1
      Background InformationSpecial AT-rich sequence-binding protein 1 (SATB1) contains 2 CUT DNA-binding domains and one homeobox DNA binding domain belonging to the CUT homeobox family. SATB1 contributes to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. SATB1 is organized into a cage-like network anchoring loops of heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex), and transcription factors recruitment. SATB1 is predominantly expressed in thymus. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic.
      References
      Product Information
      FormatAffinity Purified
      Control
      • A20 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Special AT-rich sequence-binding protein 1 using this rabbit polyclonal antibody, Anti-SATB1 Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 5 µg/mL from a representative lot detected SATB1 in human brain tissue.

      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected SATB1 in human brain cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human SATB1.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the C-terminus of SATB1.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • SATB1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~90 and ~98 kDa observed. Uniprot describes two isoforms at ~86 kDa and ~89 kDa. Uncharacterized bands may appear in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in A20 cell lysate.

      Western Blotting Analysis: 4 µg/mL of this antibody detected SATB1 in 15 µg of A20 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE602 04053252905445