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ABT121 Anti-T-cadherin (CDH13) Antibody

Anti-T-cadherin (CDH13) Antibody detects level of T-cadherin (CDH13) & has been published & validated for use in WB, IH(P).

Anti-T-cadherin (CDH13) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: CDH13, CDHH UniProt Number: P55290
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ABT121
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, B, Eq, MWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABT121
      DescriptionAnti-T-cadherin (CDH13) Antibody
      Alternate Names
      • Cadherin-13
      • Heart cadherin
      • H-cadherin
      • P105
      • Truncated cadherin
      • T-cad
      • T-cadherin
      Background InformationT-cadherin (CDH13), also known as Cadherin 13, is a member of the cadherin superfamily. This protein is unique from its other family members in that it lacks the cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. T-cadherin is widely expressed in the cardiovascular system. Mutations in T-cadherin have been associated with many types of cancer.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human heart tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-T-cadherin (CDH13) Antibody detects level of T-cadherin (CDH13) & has been published & validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected T-cadherin in human brain and human heart tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human T-cadherin at the Cadherin 1 domain.
      EpitopeCadherin 1 domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes T-cadherin at the Cadherin 1 domain. This antibody detects the ~130 kDa pro-protein and the proteolytically cleaved ~105 kDa mature isoforms. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.)
      Species Reactivity
      • Human
      • Rat
      • Bovine
      • Horse
      • Mouse
      Species Reactivity NoteDemonstrated to react with Human and Rat. Predicted to react with Bovine, Equine, and Mouse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011].
      Gene Symbol
      • CDH13
      • CDHH
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

      SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor › GPI-anchor

      TISSUE SPECIFICITY: Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.

      DEVELOPMENTAL STAGE: Expressed at higher levels in adult brain than in developing brain.

      SEQUENCE SIMILARITIES: Contains 5 cadherin domains.
      Molecular Weight~130 and ~105 kDa observed.
      ~130 kDa corresponds to the pro-protein and ~105 kDa corresponds to the proteolytically cleaved mature isoform. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human heart tissue lysate.

      Western Blot Analysis: 0.1 µg/mL of this antibody detected T-cadherin on 10 µg of human heart tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABT121 04053252436789

      Documentation

      Anti-T-cadherin (CDH13) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-T-cadherin (CDH13) Antibody Certificates of Analysis

      TitleLot Number
      Anti-T-cadherin (CDH13) - 2382195 2382195
      Anti-T-cadherin (CDH13) - 2459659 2459659
      Anti-T-cadherin (CDH13) - 2069388 2069388
      Anti-T-cadherin (CDH13) - 2153061 2153061
      Anti-T-cadherin (CDH13) - 2205026 2205026
      Anti-T-cadherin (CDH13) - 2266778 2266778
      Anti-T-cadherin (CDH13) - 2564871 2564871
      Anti-T-cadherin (CDH13) - 2931215 2931215
      Anti-T-cadherin (CDH13) - 3156790 3156790
      Anti-T-cadherin (CDH13) - 3277591 3277591
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