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MAB2613 Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12

Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12 is an antibody against UPAR-Associated Protein for use in WB, IH.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Gene Symbol: MRC2, CD280, CLEC13E, ENDO180, UPARAP UniProt Number: Q9UBG0
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MAB2613
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB2613
      DescriptionAnti-UPAR-Associated Protein Antibody, clone 2.h.9:F12
      Alternate Names
      • CD280
      • Endocytic receptor 180
      • Macrophage mannose receptor 2
      • UPAR-associated protein
      • Urokinase receptor-associated protein
      • Endocytic receptor 180
      • C-type mannose receptor 2
      Background InformationUrokinase plasminogen activator receptor-associated protein (uPARAP/Endo180/MRC2) is a member of the macrophage mannose receptor family of endocytic transmembrane glycoproteins. UPAR-Associated Protein is a membrane protein involved in matrix turnover during tissue remodeling, particularly the uptake and intracellular degradation of collagen, (Sulek, 2007).
      References
      Product Information
      FormatPurified
      Control
      • U937 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-UPAR-Associated Protein Antibody, clone 2.h.9:F12 is an antibody against UPAR-Associated Protein for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenuPAR D3-tagged recombinant protein corresponding to human UPAR-Associated Protein.
      EpitopeUnknown
      Clone2.h.9:F12
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThe antibody recognizes UPAR-Associated Protein.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryMRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al., 2007 [PubMed 17974964]).[supplied by OMIM].
      Gene Symbol
      • MRC2
      • CD280
      • CLEC13E
      • ENDO180
      • UPARAP
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).

      SUBUNIT STRUCTURE: Interacts with C-terminal region of type I collagen/COL1A1 By similarity. Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICITY: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.

      DOMAIN: C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.

      Fibronectin type-II domain mediates collagen-binding.

      Ricin B-type lectin domain contacts with the second C-type lectin domain By similarity.

      PTM: Phosphorylated.

      N-glycosylated.

      SEQUENCE SIMILARITIES: Contains 8 C-type lectin domains.

      Contains 1 fibronectin type-II domain.

      Contains 1 ricin B-type lectin domain.
      Molecular Weight ~ 180 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in U937 cell lysate.

      Western Blot Analysis: 0.2 µg/ml of this antibody detected UPAR-Associated Protein on 10 µg of U937 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB2613 04053252611025

      Documentation

      Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12 Certificates of Analysis

      TitleLot Number
      Anti-UPAR-Associated Protein, -2586850 2586850
      Anti-UPAR-Associated Protein, -2631320 2631320
      Anti-UPAR-Associated Protein, clone 2.h.9:F12 2882875
      Anti-UPAR-Associated Protein, clone 2.h.9:F12 - 2277874 2277874
      Anti-UPAR-Associated Protein, clone 2.h.9:F12 - 3223398 3223398
      Anti-UPAR-Associated Protein, clone 2.h.9:F12 - 3477811 3477811
      Anti-UPAR-Associated Protein, clone 2.h.9:F12 - 3684689 3684689
      Anti-UPAR-Associated Protein, clone 2.h.9:F12 - 3761815 3761815
      Anti-UPAR-Associated Protein, clone 2.h.9:F12 - 3869149 3869149
      Anti-UPAR-Associated Protein, clone 2.h.9:F12 - 3944161 3944161
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