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ABE1363 Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) Antibody

This Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) Antibody is validated for use in Western Blotting and Immunocytochemistry and Chromatin Immunoprecipitation (ChIP) and ChIP-seq and Dot Blot and ELISA for the detection of acetyl Histone H2A.Z (Lys 5, 7, 11).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: H2AFZ, H2AZ UniProt Number: P0C0S5
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ABE1363
50 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ICC, ChIP, ChIP-seq, DB, ELISARbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1363
      DescriptionAnti-acetyl Histone H2A.Z (Lys 5, 7, 11) Antibody
      Alternate Names
      • Histone H2A.Z
      • H2A/z
      Background InformationH2A.Z, also known as H2AFZ, is a variant of histone H2A that is highly conserved from yeast to humans. Like other histone variants, H2A.Z is encoded by a unique gene, resulting in a slightly divergent type of H2A with specialized functions. H2A.Z is involved in chromatin compaction by stabilizing the histone octamer within the nucleosome. It promotes gene expression through the creation of an open domain of chromatin that is more easily transcribed. H2A.Z is nonrandomly distributed throughout the genome, targeted primarily to pericentric heterochromatin, but excluded from the inactive X chromosome and the nucleolus. H2A.Z is associated with both euchromatin and facultative heterochromatin. DNA methylation can influence chromatin structure and effect gene silencing by excluding H2A.Z, and likewise, H2A.Z protects genes from DNA methylation. Thus, H2A.Z plays a role in regulating heterochromatin silencing and is involved in transcriptional control.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide and 0.05% ProClin300.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) Antibody is validated for use in Western Blotting and Immunocytochemistry and Chromatin Immunoprecipitation (ChIP) and ChIP-seq and Dot Blot and ELISA for the detection of acetyl Histone H2A.Z (Lys 5, 7, 11).
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Chromatin Immunoprecipitation (ChIP)
      • ChIP-seq
      • Dot Blot
      • ELISA
      Application NotesChromatin Immunoprecipitation Analysis: A representative lot immunoprecipitated acetyl Histone H2A.Z (Lys 5, 7, 11) using chromatin from HeLa cells.
      Dot Blot Analysis: 0.05 ug/mL from a representative lot detected acetyl Histone H2A.Z (Lys 5, 7, 11) in H2A.Z peptides.
      Chromatin Immunoprecipitation (Seq.) Analysis: A representative lot immunoprecipitated acetyl Histone H2A.Z (Lys 5, 7, 11) using chromatin from K562 cells.
      Immunocytochemistry Analysis: A representative lot detected acetyl Histone H2A.Z (Lys 5, 7, 11) in HeLa cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human acetyl Histone H2A.Z (Lys 5, 7, 11) near the N-terminus.
      EpitopeNear N-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityHuman, mouse, wide range expected.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • H2AFZ
      • H2AZ
      Modifications
      • Acetylation
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~16 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceWestern Blotting Analysis: 0.5 µg/mL from a representative lot detected acetyl Histone H2A.Z (Lys 5, 7, 11) in 10 µg of sodium butyrate treated HeLa acid extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1363 04055977073256

      Documentation

      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) Antibody Certificates of Analysis

      TitleLot Number
      Anti-acetyl Histone H2A.Z (Lys 5, 7, -2806072 2806072
      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) 3074944
      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) Q2464808
      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) - 3291869 3291869
      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) - 3385869 3385869
      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) - 3451442 3451442
      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) - 3521079 3521079
      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) - 3700446 3700446
      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) - 3822790 3822790
      Anti-acetyl Histone H2A.Z (Lys 5, 7, 11) - 3929929 3929929
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies