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189497 Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem

A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

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189497
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
315702-99-9C₁₅H₁₃N₃S

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      		 Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
      Catalogue Number189497
      Brand Family Calbiochem®
      SynonymsN-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
      References
      ReferencesTurcotte, S., et al. 2008. Cancer Cell 14, 90.
      Product Information
      CAS number315702-99-9
      FormBeige solid
      Hill FormulaC₁₅H₁₃N₃S
      Chemical formulaC₁₅H₁₃N₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-41

      Harmful if swallowed.
      Risk of serious damage to eyes.
      S PhraseS: 26-39

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      189497-10MGCN 04055977221855

      Documentation

      Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      189497

      References

      Reference overview
      Turcotte, S., et al. 2008. Cancer Cell 14, 90.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-August-2009 RFH
      SynonymsN-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
      DescriptionA cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number315702-99-9
      Chemical formulaC₁₅H₁₃N₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Toxic
      ReferencesTurcotte, S., et al. 2008. Cancer Cell 14, 90.