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407325 Interferon-α-IFNα-R Interaction Inhibitor - Calbiochem

The Interferon-α-IFNα-R Interaction Inhibitor controls the biological activity of Interferon-α-IFNα-R.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IFN-α Inhibitor, N-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl

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407325
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₁₇NS •HCl

Pricing & Availability

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407325-25MGCN
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      		 Glass bottle 25 mg
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      Description
      OverviewA nonpeptidic thiophenylmethanamine compound that binds interferon-α (Kd = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC50 <4.5 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).
      Catalogue Number407325
      Brand Family Calbiochem®
      SynonymsIFN-α Inhibitor, N-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl
      References
      ReferencesGeppert, T., et al. 2011. Angew. Chem. Int. Ed. 51, 258.
      Product Information
      FormWhite solid
      Hill FormulaC₁₈H₁₇NS •HCl
      Chemical formulaC₁₈H₁₇NS •HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407325-25MGCN 04055977188349

      Documentation

      Interferon-α-IFNα-R Interaction Inhibitor - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Interferon-α-IFNα-R Interaction Inhibitor - Calbiochem Certificates of Analysis

      TitleLot Number
      407325

      References

      Reference overview
      Geppert, T., et al. 2011. Angew. Chem. Int. Ed. 51, 258.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-September-2012 JSW
      SynonymsIFN-α Inhibitor, N-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl
      DescriptionA nonpeptidic thiophenylmethanamine compound that binds interferon-α (Kd = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA (vaccinia virus Ankara) infection (IC50 <4.5 µM), TLR9 ligand CpG2216 stimulation, VSV-M2 (vesicular stomatitis virus variant 2) infection, or MDA5/TLR3 ligand poly(I:C) stimulation (by >95% inhibition at 9 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₇NS •HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml; clear, colorless solution)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGeppert, T., et al. 2011. Angew. Chem. Int. Ed. 51, 258.