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SCC261 Oli-neu Mouse Oligodendroglial Precursor Cell Line

The Oli-neu cell line is a versatile cellular model for oligodendrocyte biology and associated neurophysiological investigations.

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SCC261
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC261
      DescriptionOli-neu Mouse Oligodendroglial Precursor Cell Line
      OverviewOli-neu is an immortalized mouse oligodendroglial cell line that recapitulates morphology and in vivo physiological activity of oligodendroglial cells. Oli-neu cells differentiate into oligodendrocytes upon daily addition of 1 mM dibutyrl-cAMP.2 Oli-neu cells have been utilized in a broad range of studies of oligodendrocyte biology and has greatly contributed to the understanding of the mechanisms of myelination and molecular players in myelination disorders. Differentiated Oli-neu oligodendrocytes express O4 antigen, an oligodendrocyte marker, and manifest cell processes characteristic of oligodendrocyte morphology.2 The Oli-neu cell line is a versatile cellular model for oligodendrocyte biology and associated neurophysiological investigations.
      Alternate Names
      • olineu
      • oliNeu
      • OLIneu
      Background InformationOligodendrocytes, comprising 5-10% of the total population of glial cells in the central nervous system, are responsible for producing the myelin sheath encasing axons which is essential for efficient electric conduction of neural impulses.1 Oligodendrocytes arise from precursor cells that differentiate just before birth. Disorders of myelination of axons can lead to emergence of neurodegenerative diseases such as Alzheimer’s and multiple sclerosis, underscoring the critical importance of understanding oligodendrocyte biology and interactions. The myelination process occurs within the complex milieu of neuronal cell types, thus is difficult to reconstruct without cellular models.

      Oli-neu is an immortalized mouse oligodendroglial cell line that recapitulates morphology and in vivo physiological activity of oligodendroglial cells. Oli-neu cells differentiate into oligodendrocytes upon daily addition of 1 mM dibutyrl-cAMP.2 Oli-neu cells have been utilized in a broad range of studies of oligodendrocyte biology and has greatly contributed to the understanding of the mechanisms of myelination and molecular players in myelination disorders. Differentiated Oli-neu oligodendrocytes express O4 antigen, an oligodendrocyte marker, and manifest cell processes characteristic of oligodendrocyte morphology.2 The Oli-neu cell line is a versatile cellular model for oligodendrocyte biology and associated neurophysiological investigations.

      Source
      Oli-neu was derived from oligodendrocytes and oligodendrocyte precursor cells isolated from the cerebellum of a 6-day-old NMRI mouse and infected with retrovirus containing the t-neu tyrosine kinase oncogene.2

      References
      1. Curr Pharm Des. 2016, 22(6): 656-679.
      2. Eur J Neurosci. 1995, 7(6): 1245-1265.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationThe Oli-neu cell line is a versatile cellular model for oligodendrocyte biology and associated neurophysiological investigations.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Neural Lineage Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • Cells are tested negative for infectious diseases by a Mouse Essential CLEAR Panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of mouse origin and negative for inter-species contamination from rat, human, chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
      • Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
      Storage and Shipping Information
      Storage ConditionsOli-neu mouse oligodendrocyte precursor cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC261 04065267625324