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566322 SIRT1 Inhibitor III

The SIRT1 Inhibitor III, also referenced under CAS 49843-98-3, controls the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Cell Structure applications.

SIRT1 Inhibitor III MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527

Primary Target: SIRT1
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566322
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
49843-98-3C₁₃H₁₃ClN₂O

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566322-5MGCN
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      		 Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 µM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 µM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.
      Catalogue Number566322
      Brand Family Calbiochem®
      Synonyms6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527
      References
      ReferencesSolomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28.
      Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.
      Product Information
      CAS number49843-98-3
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₃H₁₃ClN₂O
      Chemical formulaC₁₃H₁₃ClN₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSIRT1
      Primary Target IC<sub>50</sub>98 nM against SIRT1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      566322-5MGCN 04055977191394

      Documentation

      SIRT1 Inhibitor III SDS

      Title

      Safety Data Sheet (SDS) 

      SIRT1 Inhibitor III Certificates of Analysis

      TitleLot Number
      566322

      References

      Reference overview
      Solomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28.
      Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.

      Data Sheet

      Title
      SIRTainty™ Class III HDAC Assay
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-July-2007 JSW
      Synonyms6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527
      DescriptionA cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 µM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 µM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number49843-98-3
      Chemical formulaC₁₃H₁₃ClN₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesSolomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28.
      Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045.