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531889 STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: c[G(2ʹ,5ʹ)pA(3ʹ,5ʹ)p], 2ʹ,5ʹ-3ʹ,5ʹ-cGAMP

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531889
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1441190-66-4C₂₀H₂₄N₁₀O₁₃P₂ (free acid)

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      Description
      OverviewA cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4 nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 = 20 nM). Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1. Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′,2′-cGAMP, and 3′,3′-cGAMP and about 75 fold greater affinity over 2′,2′-cGAMP.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531889
      Brand Family Calbiochem®
      Synonymsc[G(2ʹ,5ʹ)pA(3ʹ,5ʹ)p], 2ʹ,5ʹ-3ʹ,5ʹ-cGAMP
      References
      ReferencesWu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
      Zhang, X., et al. 2013. Mol. Cell. 51, 226.
      Wu, J., et al. 2013. Science. 339, 26.
      Product Information
      CAS number1441190-66-4
      FormWhite solid
      Hill FormulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
      Chemical formulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSTING
      Primary Target K<sub>i</sub>4 nM, EC₅₀
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.31889.0001 04055977260014

      Documentation

      STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      531889

      References

      Reference overview
      Wu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
      Zhang, X., et al. 2013. Mol. Cell. 51, 226.
      Wu, J., et al. 2013. Science. 339, 26.

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products - Antibodies, Small Molecule, Inhibitors

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-December-2014 JSW
      Synonymsc[G(2ʹ,5ʹ)pA(3ʹ,5ʹ)p], 2ʹ,5ʹ-3ʹ,5ʹ-cGAMP
      DescriptionA cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4 nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 = 20 nM). Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1. Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′,2′-cGAMP, and 3′,3′-cGAMP and about 75 fold greater affinity over 2′,2′-cGAMP.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1441190-66-4
      Chemical formulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
      Purity≥98% by HPLC
      SolubilityH₂O
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
      Zhang, X., et al. 2013. Mol. Cell. 51, 226.
      Wu, J., et al. 2013. Science. 339, 26.