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14-924 TYK2 Protein, active, 10 µg

Active, TN-terminal 6His-tagged, recombinant, human TYK2, amino acids 875-end. For use in Kinase Assays.

TYK2 Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-924
10 µg  Also available in 250μg size as catalog # 14-924M and in bulk as catalog # 14-924-K.
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      Overview

      Replacement Information
      Description
      Catalogue Number14-924
      Trade Name
      • Upstate
      DescriptionTYK2 Protein, active, 10 µg
      OverviewTYK2 is member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
      References
      Product Information
      Presentation50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol
      Quality LevelMQ100
      Applications
      ApplicationActive, TN-terminal 6His-tagged, recombinant, human TYK2, amino acids 875-end. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceN-terminal 6His-tagged, recombinant, human TYK2 amino acids 875-end, expressed by baculovirus in Sf21 insect cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • TYK2
      • JTK1
      Protein TargetTYK2
      Purification MethodPurified using immobilized metal affinity chromatography followed by gel filtration.
      Target Sub-FamilyTK
      UniProt Number
      Molecular Weight40 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of peptide GGMEDIYFEFMGGKKK
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250μg size as catalog # 14-924M and in bulk as catalog # 14-924-K.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-924 04053252851421