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Merck

GF037

Thrombopoietin, human

>98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized, suitable for cell culture

Synonym(s):

MGDF, Mpl-ligand, TPO

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.75

Key Documents

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Product Name

Thrombopoietin, TPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation & maturation of megakaryocytes & promotes increased circulating levels of platelets in vivo.

biological source

human

assay

>98% (SDS-PAGE and HPLC)

specific activity

≥1x10(e6) U/mg

manufacturer/tradename

Chemicon®

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 ng/mg Endotoxin (of human TPO; 1 EU/μg)

input

sample type hematopoietic stem cell(s)

NCBI accession no.

NM_000460.2
NM_199228.1
NM_199356.1

UniProt accession no.

P40225

shipped in

dry ice

Quality Level

100

Gene Information

human ... TPO(7173)

Related Categories

Biochem/physiol Actions

The ED50 was determined by the dose-dependent stimulation of the proliferation of M07e cells is ≤1.0 ng/mL

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Product Source: E.coli
TPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. Chemicon′s Human TPO is a soluble 18.5 kDa protein containing 174 amino acid residues which comprises the receptor binding domain of the Mpl-ligand protein.

Physical form

Lyophilized protein from 5mM Tris, pH 7.6, with no additives.

Preparation Note

The lyophilized powder, though stable at room temperature, is best stored at -20°C. Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.5-1.0 mg/mL. This solution can be diluted into other aqueous buffers and stored at 4ºC for 1 week or -20ºC for future use. Reconstituted TPO should be stored in working aliquots at -20°C.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
GF03708436037125003

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