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SCC189 UM-SCC-105 Human Squamous Carcinoma Cell Line

The HPV18-positive SCC-105 squamous cell carcinoma cell line was derived from the laryngeal tumor of a 51yo never-smoker male and is a suitable in vitro model of H&N carcinoma studies.

SCC189
≥1X10⁶ cells/vial  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC189
      DescriptionUM-SCC-105 Human Squamous Carcinoma Cell Line
      OverviewAccess to UM-SCC-105 Cells is limited solely to those officers, employees and students of PURCHASER’s institution who need access to perform research. PURCHASER may not distribute UM-SCC-105 Cells or derivatives to third parties. PURCHASER shall comply with all applicable laws in its use and handling of the Product and shall keep it under reasonable safe and secure conditions to prevent unauthorized use or access.

      THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS LIMITED USE LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF UM-SCC-105 CELLS, INCLUDING LICENSING TO COMMERCIAL ENTITIES, PLEASE CONTACT: licensing@milliporesigma.com.
      Alternate Names
      • UMSCC-105
      • Squamous cell carcinoma cell line
      • Human squamous cell carcinoma cell line
      • Human SCC cell line
      Background InformationHPV-related head and neck cancers are often more responsive with current therapeutic protocols when compared to HPV-negative tumors that are derived from the same anatomical location. This has propagated interest in reducing the intensity levels of treatment. However, even when combining strong therapeutic approaches with chemotherapy, 20-30% of HPV-positive cancers progress and no longer respond to treatment methods. This makes it continually important to understand why certain tumors progress while others appropriately respond to treatment. ​​The UM-SCC-105 cell line is HPV18-positive. This cell line was biopsied from a laryngeal tumor of a 51-year-old never-smoker male individual. It is understood that the cancer progression was driven by E6/E7 viral mechanisms rather than cell cycle mutations typically related to tobacco smoke carcinogenesis, giving this cell line a unique background. Other mechanisms, such as understanding viral integration into the host genome, continue to be an important aspect of understanding HPV-driven cancers. The UM-SCC-105 cell line positively expresses head and neck cancer markers such as ALDH1, CD44, and ABCG2. ALDH1 and CD44 have both been implicated as cancer stem cell (CSC) markers in head and neck cancers. CSCs are often associated with a poor prognosis and are necessary to understanding aggressive tumor behavior that overcomes treatment. ABCG2 is also addressed as a common head and neck squamous cell carcinoma marker. ABCG2 functions as an efflux pump and is associated with anticancer drug resistance.

      Source: The UM-SCC-105 cell line is derived from a biopsied laryngeal tumor of a 51-year-old “never smoker” male.​

      References:
      1. Front Oncol. (2021); 11: 606010.
      2. Head Neck (2016); 38(Suppl 1): E459-E467.
      3. Head Neck (2017); 39(5): 840-852.
      4. Exp Ther Med (2011); 2(6): 1151-1157.
      References
      Product Information
      Components
      • ≥1x106 viable UM-SCC-105 Cells: (Catalog No. SCC189). Store in liquid nitrogen.
      Quality LevelMQ100
      Applications
      ApplicationThe HPV18-positive SCC-105 squamous cell carcinoma cell line was derived from the laryngeal tumor of a 51yo never-smoker male and is a suitable in vitro model of H&N carcinoma studies.
      Key Applications
      • Cell Culture
      Application NotesThis product is available for sale to academic institutions or not-for-profit entities for research use. For information on commercial licensing please contact licensing@milliporesigma.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • UM-SCC-105 cells are verified to be of human origin and negative for mouse, rat, Chinese hamster, Golden Syrian hamster, and non-human primate interspecies contamination, as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
      • Cells tested negative for infectious diseases against a Human Essential CLEAR panel by Charles River Animal Diagnostic Services (Cells are HPV18-Positive.)
      • Cells tested negative for mycoplasma.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsUM-SCC-105 cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC189 04065269270812