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Merck

627624

D-Val-Phe-Lys Chloromethyl Ketone, Dihydrochloride

Selective irreversible inhibitor of plasmin with high selectivity for plasmin (IC50 = 100 pM for human plasmin) over urokinase.

Synonym(s):

Plasmin Inhibitor, 2HCl

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About This Item

NACRES:
NA.77
UNSPSC Code:
12352202

Key Documents

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Product Name

D-Val-Phe-Lys Chloromethyl Ketone, Dihydrochloride, Selective irreversible inhibitor of plasmin with high selectivity for plasmin (IC50 = 100 pM for human plasmin) over urokinase.

assay

≥90% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

off-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

Quality Level

100

storage temp.

2-8°C

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
Human plasmin
Product does not compete with ATP.
Reversible: no
Target IC50: 100 pM for human plasmin

Disclaimer

Toxicity: Standard Handling (A)

General description

Selective irreversible inhibitor of plasmin with high selectivity for plasmin (IC50 = 100 pM for human plasmin) over urokinase.

Other Notes

H-D-Val-Phe-Lys-CMK
Woessner, J.F., Jr., et al. 1989. Steroids54, 491.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.







From Catalog:

Desc. Field- added "(IC₅₀ = 100 pM for human plasmin) "

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hasam Madarati et al.
Scientific reports, 14(1), 9073-9073 (2024-04-21)
ADAMTS13, a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13, regulates the length of Von Willebrand factor (VWF) multimers and their platelet-binding activity. ADAMTS13 is constitutively secreted as an active protease and is not inhibited by circulating

Global Trade Item Number

SKUGTIN
627624-5MGCN04055977262858

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