AB5888
Anti-NOGO A Antibody
Chemicon®, from rabbit
Synonym(s):
Neurite outgrowth inihibitor A
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
12
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, rat
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Rtn4(68585)
General description
Theoretical MW is approx. 126 kDa however literature reports observed molecular weight to be 205 kDa to 220 kDa
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified
Application
Anti-NOGO A Antibody detects level of NOGO A & has been published & validated for use in WB.
Biochem/physiol Actions
Cat. # AB5888 is specific to NOGO A. It does not recognize NOGO B or NOGO C.
Reactivity with other species has not been tested.
Analysis Note
Routinely tested on mouse brain lysate
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Feng Tan et al.
Experimental and therapeutic medicine, 16(6), 4943-4950 (2018-12-14)
Electroacupuncture (EA) may stimulate neurogenesis in animal models of ischemic stroke; however, the associated mechanisms are not clear. The present study aimed to evaluate the neurogenesis efficacy of EA on ischemic stroke and the underlying associated mechanisms. A model of
Giuseppe Vaccaro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(20), 4087-4100 (2022-04-20)
Nogo-66 receptors (NgR1-3) are glycosylphosphatidyl inositol-linked proteins that belong to the leucine-rich repeat superfamily. Through binding to myelin-associated inhibitors, NgRs contribute to the inhibition of axonal regeneration after spinal cord injury. Their role in limiting synaptic plasticity and axonal outgrowth
Jae Young Lee et al.
Scientific reports, 7(1), 8958-8958 (2017-08-23)
Axo-glial units are highly organised microstructures propagating saltatory conduction and are disrupted during multiple sclerosis (MS). Nogo receptor 1 (NgR1) has been suggested to govern axonal damage during the progression of disease in the MS-like mouse model, experimental autoimmune encephalomyelitis
Ryan L O'Hare Doig et al.
BMC neuroscience, 18(1), 62-62 (2017-08-16)
Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not
María Nazareth González-Alvarado et al.
Glia, 70(3), 522-535 (2021-11-18)
Recently, oligodendrocytes (Ol) have been attributed potential immunomodulatory effects. Yet, the exact mode of interaction with pathogenic CNS infiltrating lymphocytes remains unclear. Here, we attempt to dissect mechanisms of Ol modulation during neuroinflammation and characterize the interaction of Ol with
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| AB5888 | 04053252618680 |
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