196878 (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem

196878
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₆H₁₅F₃N₂O₄ 93468-89-4

      가격 및 재고여부

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      196878-1MGCN
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          Plastic ampoule 1 mg
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          196878-5MGCN
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              Plastic ampoule 5 mg
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              Description
              OverviewSynthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
              Catalogue Number196878
              Brand Family Calbiochem®
              Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
              References
              ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
              Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
              Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
              Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
              Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
              Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
              Tagliatela, M., et al. 1986. Brain Res. 381, 356.
              Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
              Product Information
              CAS number93468-89-4
              ATP CompetitiveN
              FormYellow solid
              Hill FormulaC₁₆H₁₅F₃N₂O₄
              Chemical formulaC₁₆H₁₅F₃N₂O₄
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetL-type Ca2+ channel
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 36/38

              Irritating to eyes and skin.
              S PhraseS: 26-36

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Irritant
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem MSDS

              타이틀

              물질안전보건자료(MSDS) 

              (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem Certificates of Analysis

              TitleLot Number
              196878

              References

              참고문헌 보기
              Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
              Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
              Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
              Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
              Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
              Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
              Tagliatela, M., et al. 1986. Brain Res. 381, 356.
              Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision02-February-2009 JSW
              Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
              DescriptionA synthetic dihydropyridine derivative that is an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
              FormYellow solid
              CAS number93468-89-4
              Chemical formulaC₁₆H₁₅F₃N₂O₄
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityEthanol (35 mg/ml) or DMSO (35 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
              Toxicity Irritant
              ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
              Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
              Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
              Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
              Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
              Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
              Tagliatela, M., et al. 1986. Brain Res. 381, 356.
              Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.