260585 5ʹ-Deoxy-5ʹ-methylthioadenosine - CAS 2457-80-9 - Calbiochem

260585
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Empirical FormulaCAS #
C₁₁H₁₅N₅O₃S 2457-80-9

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260585-50MGCN
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      Plastic ampoule 50 mg
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      Description
      OverviewA cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells.
      Catalogue Number260585
      Brand Family Calbiochem®
      SynonymsMTA, MeSAdo
      References
      ReferencesLee, S.H., and Cho, Y.D. 1998. Exp. Cell Res. 240, 282.
      Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res. 51, 53.
      Joy, A., et al. 1997. Oncogene 14, 171.
      Riscoe, M.K., et al. 1984. Biochem. Pharmacol. 33, 3639.
      Product Information
      CAS number2457-80-9
      FormWhite solid
      Hill FormulaC₁₁H₁₅N₅O₃S
      Chemical formulaC₁₁H₁₅N₅O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetprotein carboxymethyltranferase
      Secondary targetFGF-2receptor tyrosine kinase activity
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSAU7410000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      5ʹ-Deoxy-5ʹ-methylthioadenosine - CAS 2457-80-9 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      5ʹ-Deoxy-5ʹ-methylthioadenosine - CAS 2457-80-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      260585

      References

      참고문헌 보기
      Lee, S.H., and Cho, Y.D. 1998. Exp. Cell Res. 240, 282.
      Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res. 51, 53.
      Joy, A., et al. 1997. Oncogene 14, 171.
      Riscoe, M.K., et al. 1984. Biochem. Pharmacol. 33, 3639.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      SynonymsMTA, MeSAdo
      DescriptionA naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number2457-80-9
      RTECSAU7410000
      Chemical formulaC₁₁H₁₅N₅O₃S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO or DMF (25 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Irritant
      ReferencesLee, S.H., and Cho, Y.D. 1998. Exp. Cell Res. 240, 282.
      Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res. 51, 53.
      Joy, A., et al. 1997. Oncogene 14, 171.
      Riscoe, M.K., et al. 1984. Biochem. Pharmacol. 33, 3639.

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      카테고리

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors