101500 AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem

101500
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₈H₁₀FNO₂S · HCl 30827-99-7

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      101500-100MGCN
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          Glass bottle 100 mg
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          101500-1GMCN
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              Glass bottle 1 gm
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              101500-500MGCN
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                  Plastic ampoule 500 mg
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                  101500-50MGCN
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                      Glass bottle 50 mg
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                      Description
                      OverviewSpecific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H2O (Cat. No. 508436).
                      Catalogue Number101500
                      Brand Family Calbiochem®
                      Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
                      Application Data
                      References
                      ReferencesCitron, M., et al. 1996. Neuron 17, 171.
                      Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
                      Mintz, G.R. 1993. BioPharm. 6, 34.
                      Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
                      Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
                      Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
                      Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
                      Product Information
                      CAS number30827-99-7
                      ATP CompetitiveN
                      FormWhite to off-white solid
                      Hill FormulaC₈H₁₀FNO₂S · HCl
                      Chemical formulaC₈H₁₀FNO₂S · HCl
                      ReversibleN
                      Structure formula ImageStructure formula Image
                      Quality LevelMQ100
                      Applications
                      Biological Information
                      Primary Targetchymotrypsin
                      Purity>97% by HPLC
                      Physicochemical Information
                      Cell permeableN
                      Dimensions
                      Materials Information
                      Toxicological Information
                      Safety Information according to GHS
                      Safety Information
                      Product Usage Statements
                      Storage and Shipping Information
                      Ship Code Ambient Temperature Only
                      Toxicity Standard Handling
                      Storage +15°C to +30°C
                      Protect from Moisture Protect from moisture
                      Do not freeze Ok to freeze
                      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
                      Packaging Information
                      Packaged under inert gas Packaged under inert gas
                      Transport Information
                      Supplemental Information
                      Specifications

                      Documentation

                      AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem MSDS

                      타이틀

                      물질안전보건자료(MSDS) 

                      AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem Certificates of Analysis

                      TitleLot Number
                      101500

                      References

                      참고문헌 보기
                      Citron, M., et al. 1996. Neuron 17, 171.
                      Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
                      Mintz, G.R. 1993. BioPharm. 6, 34.
                      Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
                      Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
                      Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
                      Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.

                      Brochure

                      Title
                      Bulk Product Guide

                      Citations

                      타이틀
                    • Catherine Mee-Hie Cho, Ashok Mulchandani and Wilfred Chen. (2006) Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides. Protein Engineering Design and Selection 19, 99-105.
                    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
                    • Sharon Yagur-Kroll and Orna Amster-Choder. (2005) Dynamic membrane topology of the E. coli -glucoside transporter β-glucosidase transporter BglF. Journal of Biological Chemistry 280, 19306-19318.
                    • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
                    • Data Sheet

                      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                      Revision27-September-2013 JSW
                      Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl
                      Application Data
                      DescriptionSpecific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K.
                      FormWhite to off-white solid
                      Intert gas (Yes/No) Packaged under inert gas
                      CAS number30827-99-7
                      Chemical formulaC₈H₁₀FNO₂S · HCl
                      Structure formulaStructure formula
                      Purity>97% by HPLC
                      SolubilityH₂O (25 mg/ml)
                      Storage +15°C to +30°C
                      Protect from moisture
                      Do Not Freeze Ok to freeze
                      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9).
                      Toxicity Standard Handling
                      ReferencesCitron, M., et al. 1996. Neuron 17, 171.
                      Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
                      Mintz, G.R. 1993. BioPharm. 6, 34.
                      Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
                      Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
                      Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
                      Baker, B.R., and Cory, M. 1971. J. Med. Chem. 14, 119.
                      Citation
                    • Catherine Mee-Hie Cho, Ashok Mulchandani and Wilfred Chen. (2006) Functional analysis of organophosphorus hydrolase variants with high degradation activity towards organophosphate pesticides. Protein Engineering Design and Selection 19, 99-105.
                    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
                    • Sharon Yagur-Kroll and Orna Amster-Choder. (2005) Dynamic membrane topology of the E. coli -glucoside transporter β-glucosidase transporter BglF. Journal of Biological Chemistry 280, 19306-19318.
                    • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
                    • 관련 제품 및 어플리케이션

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                      카테고리

                      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors