171262 AMPK Activator V, Ampkinone - Calbiochem

171262
가격 및 재고 조회

개요

Replacement Information

주요 사양표

Empirical Formula
C₃₁H₂₃NO₆

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
171262-5MGCN
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable benzopyran compound that stimulates both LKB1 and CaMKK-mediated AMPK activity indirectly with no noticeable effect on purified AMPK, cellular AMP/ATP ratio, PI 3-K/Akt signaling and respiratory chain, and displays antidiabetic and antiobesity properties. Shown to induce phosphorylation of AMPK-Thr172 and ACC-Ser79 in L6 cells (EC50 = 4.3 µM), C2C12 myocytes, 3T3-L1 preadipocytes and HepG2 hepatic cells, and enhance glucose uptake and insulin sensitivity in high fat-diet-induced obesity mouse model (10 mg/kg, s.c.) with the lowering of cholesterol and nonesterified fatty acids.
      Catalogue Number171262
      Brand Family Calbiochem®
      SynonymsAKN, AMPK Signaling Activator V
      References
      ReferencesOh, S., et al. 2010. J. Med. Chem. 53, 7405.
      Product Information
      FormYellow powder
      Hill FormulaC₃₁H₂₃NO₆
      Chemical formulaC₃₁H₂₃NO₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AMPK Activator V, Ampkinone - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      AMPK Activator V, Ampkinone - Calbiochem Certificates of Analysis

      TitleLot Number
      171262

      References

      참고문헌 보기
      Oh, S., et al. 2010. J. Med. Chem. 53, 7405.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-September-2012 JSW
      SynonymsAKN, AMPK Signaling Activator V
      DescriptionA cell-permeable benzopyran compound that stimulates both LKB1 and CaMKK-mediated AMPK activity indirectly with no noticeable effect on purified AMPK, cellular AMP/ATP ratio, PI 3-K/Akt signaling and respiratory chain, and displays antidiabetic and antiobesity properties. Shown to induce phosphorylation of AMPK-Thr172 and ACC-Ser79 in L6 cells (EC50 = 4.3 µM), C2C12 myocytes, 3T3-L1 preadipocytes and HepG2 hepatic cells, and enhance glucose uptake and insulin sensitivity in high fat-diet-induced obesity mouse model (10 mg/kg, s.c.) with the lowering of cholesterol and nonesterified fatty acids.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₁H₂₃NO₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesOh, S., et al. 2010. J. Med. Chem. 53, 7405.