118500 ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem

118500
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₂₁H₁₇NO₃S₂ 587871-26-9

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      118500-10MGCN
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          Glass bottle 10 mg
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          118500-2MGCN
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              Glass bottle 2 mg
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              Description
              OverviewA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5 , 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 = µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502) in DMSO is also available.
              Catalogue Number118500
              Brand Family Calbiochem®
              Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
              References
              ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
              Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
              Hickson, I., et al. 2004. Cancer Res. 64, 9152.
              Product Information
              CAS number587871-26-9
              ATP CompetitiveY
              FormWhite solid
              Hill FormulaC₂₁H₁₇NO₃S₂
              Chemical formulaC₂₁H₁₇NO₃S₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetATM Kinase
              Primary Target IC<sub>50</sub>13 nM
              Primary Target K<sub>i</sub>2.2 nM for ATM kinase
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped with Blue Ice or with Dry Ice
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem MSDS

              타이틀

              물질안전보건자료(MSDS) 

              ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem Certificates of Analysis

              TitleLot Number
              118500

              References

              참고문헌 보기
              Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
              Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
              Hickson, I., et al. 2004. Cancer Res. 64, 9152.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision06-February-2014 JSW
              Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
              DescriptionA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number587871-26-9
              Chemical formulaC₂₁H₁₇NO₃S₂
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (4 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Standard Handling
              ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
              Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
              Hickson, I., et al. 2004. Cancer Res. 64, 9152.