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114700 Activin A, Human, Recombinant, CHO Cells

114700
가격 및 재고 조회

개요

Replacement Information

주요 사양표

Purity
≥95% by SDS-PAGE

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
114700-10UGCN
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      Plastic ampoule 10 μg
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      Description
      OverviewRecombinant, human activin A (disulfide-linked homodimer of two 116-amino acid residue βA subunits) expressed in CHO cells. Mature βA-monomer lacks a potential N-linked glycosylation site and has a calculated molecular weight of 13 kDa. A member of the TGF-β superfamily that is involved in the negative regulation of B lineage lymphocytes. Shown to play an important role in the regulation of hormonogenesis, cellular homeostasis, and differentiation programs. Reported to inhibit endogenous production of IL-6.
      Catalogue Number114700
      Brand Family Calbiochem®
      References
      ReferencesZipori, D., et al. 2001. J. Leukoc. Biol. 69, 867.
      Hedger, M.P., et al. 2000. Cytokine 12, 595.
      Woodruff, T.K. 1998. Biochem. Pharmacol. 55, 953.
      Ying, S.Y., et al. 1997. Proc. Soc. Exp. Biol. Med. 214, 114.
      Schwall, R.H., and Lei, C. 1991. Methods Enzymol. 198, 340.
      Mason, A., et al. 1986. Biochem. Biophys. Res. Commun. 135, 957.
      Product Information
      FormLyophilized
      FormulationLyophilized from sterile filtered 35% acetonitrile, 0.1% TFA, 50 µg BSA/µg Activin A.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀ = 0.5-2.0 ng/ml as measured by its ability to induce hemoglobin expression in K562 cells
      Purity≥95% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤100 pg/µg Activin A
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Activin A, Human, Recombinant, CHO Cells Certificates of Analysis

      TitleLot Number
      114700

      References

      참고문헌 보기
      Zipori, D., et al. 2001. J. Leukoc. Biol. 69, 867.
      Hedger, M.P., et al. 2000. Cytokine 12, 595.
      Woodruff, T.K. 1998. Biochem. Pharmacol. 55, 953.
      Ying, S.Y., et al. 1997. Proc. Soc. Exp. Biol. Med. 214, 114.
      Schwall, R.H., and Lei, C. 1991. Methods Enzymol. 198, 340.
      Mason, A., et al. 1986. Biochem. Biophys. Res. Commun. 135, 957.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      DescriptionRecombinant, human activin A (disulfide-linked homodimer of two 116-amino acid residue βA subunits) expressed in CHO cells. Mature βA-monomer lacks a potential N-linked glycosylation site and has a calculated molecular mass of 13 kDa. Activins are members of the TGF-β superfamily and have been shown to play an important role in the regulation of homonogenesis, cellular homeostasis, and differentiation programs.
      FormLyophilized
      FormulationLyophilized from sterile filtered 35% acetonitrile, 0.1% TFA, 50 µg BSA/µg Activin A.
      Purity≥95% by SDS-PAGE
      ContaminantsEndotoxin: ≤100 pg/µg Activin A
      Biological activityED₅₀ = 0.5-2.0 ng/ml as measured by its ability to induce hemoglobin expression in K562 cells
      SolubilityReconstitute to a concentration ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesZipori, D., et al. 2001. J. Leukoc. Biol. 69, 867.
      Hedger, M.P., et al. 2000. Cytokine 12, 595.
      Woodruff, T.K. 1998. Biochem. Pharmacol. 55, 953.
      Ying, S.Y., et al. 1997. Proc. Soc. Exp. Biol. Med. 214, 114.
      Schwall, R.H., and Lei, C. 1991. Methods Enzymol. 198, 340.
      Mason, A., et al. 1986. Biochem. Biophys. Res. Commun. 135, 957.