114802 AdaAhx₃L₃VS - CAS 389064-25-9 - Calbiochem

114802
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₅₀H₈₈N₆O₈S 389064-25-9

      가격 및 재고여부

      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      114802-250UGCN
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          Plastic ampoule 250 μg
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          Description
          OverviewA potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.
          Catalogue Number114802
          Brand Family Calbiochem®
          SynonymsAdamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)₃-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI
          References
          ReferencesKessler, B.M., et al. 2001. Chem. Biol. 8, 913.
          Product Information
          CAS number389064-25-9
          ATP CompetitiveN
          FormOff-white powder
          Hill FormulaC₅₀H₈₈N₆O₈S
          Chemical formulaC₅₀H₈₈N₆O₈S
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetchymotrypsin-like activity of the 20S proteasome
          Primary Target IC<sub>50</sub>50-100 nM against chymotrypsin-like activity of the 20S proteasome
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          AdaAhx₃L₃VS - CAS 389064-25-9 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          AdaAhx₃L₃VS - CAS 389064-25-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          114802

          References

          참고문헌 보기
          Kessler, B.M., et al. 2001. Chem. Biol. 8, 913.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsAdamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)₃-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI
          DescriptionA cell-permeable, peptide vinyl sulfone that acts as a potent, irreversible inhibitor of proteasome activity. Covalently modifies the catalytically active β-subunits of the proteasome. Shown to inhibit the chymotrypsin-like (10-50 nM), trypsin-like (1-5 µM), and the peptidyl glutamyl peptide hydrolyzing (PGPH) (0.5-1 µM) activities of purified 20S proteasomes from rabbit muscle. Inhibits proteasomal degradation of deglycosylated MHC HLA-A2 heavy chain in US11+ cells (~50 µM).
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number389064-25-9
          Chemical formulaC₅₀H₈₈N₆O₈S
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKessler, B.M., et al. 2001. Chem. Biol. 8, 913.