115500 Adenophostin A, Hexasodium Salt - Calbiochem

115500
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      개요

      Replacement Information

      주요 사양표

      Empirical Formula
      C₁₆H₂₀N₅O₁₈P₃ · 6Na

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      115500-50UGCN
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          50 μg
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          Description
          OverviewOne of the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R (EC50 = 14.7 nM for Ca2+ release from permeabilized hepatocytes). Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to enzymatic degradation.
          Catalogue Number115500
          Brand Family Calbiochem®
          References
          ReferencesCorrea, V., et al. 2001. Mol. Pharmacol. 59, 1206.
          Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
          DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
          Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
          Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
          Hirota, J., et al. 1995. FEBS Lett. 368, 248.
          Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
          Chemical formulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationAdenophostin A, Hexasodium Salt, is a potent agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3.
          Biological Information
          Primary TargetType 1 inositol 1,4,5-trisphosphate receptor (InsP3R)
          Primary Target IC<sub>50</sub>EC50 = 10.9 nM against InsP3R
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Adenophostin A, Hexasodium Salt - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Adenophostin A, Hexasodium Salt - Calbiochem Certificates of Analysis

          TitleLot Number
          115500

          References

          참고문헌 보기
          Correa, V., et al. 2001. Mol. Pharmacol. 59, 1206.
          Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
          DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
          Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
          Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
          Hirota, J., et al. 1995. FEBS Lett. 368, 248.
          Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          DescriptionA glyconucleotide originally isolated from the culture broth of Penicillium brevicompactum. Adenophostin A is the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R). Exhibits about 50-100 fold greater affinity for the InsP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R. Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to degradation by the enzymes that metabolize (1,4,5)InsP3.
          FormWhite solid
          Chemical formulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesCorrea, V., et al. 2001. Mol. Pharmacol. 59, 1206.
          Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
          DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
          Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
          Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
          Hirota, J., et al. 1995. FEBS Lett. 368, 248.
          Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.

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          Accessories (Primary)

          카탈로그 번호 설명  
          101114 Withdrawal system for solvents with manual pressure build-up for 10 l and 25 l drums 가격 및 재고 조회
          106710 Withdrawal system for stainless steel barrels and drums 가격 및 재고 조회
          108803 Drum key 가격 및 재고 조회
          963533 Safety carrier 가격 및 재고 조회

          Accessories (Secondary)

          카탈로그 번호 설명  
          100801 Label set acc. GHS 가격 및 재고 조회
          107070 Antistatic device 가격 및 재고 조회
          108801 Bottle key 가격 및 재고 조회

          카테고리

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > IP3 and Ryanodine Channel Modulators