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116812 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem

116812
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CAS #Empirical Formula
93882-12-3C₁₆H₁₄ClN₅O₆PS · Na

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116812-10MGCN
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      Plastic ampoule 10 mg
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      Description
      OverviewCell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50 = 900 nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50 = 25 µM).
      Catalogue Number116812
      Brand Family Calbiochem®
      SynonymsAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt
      References
      Referencesde Rooij, J., et al. 1998. Nature. 396, 474.
      Kawasaki, H., et al. 1998. Science. 282, 2275.
      Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
      Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
      Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
      Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
      Datta, R., et al. 1991. Blood 78, 83.
      Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
      Sandberg, M., et al. 1991. Biochem. J. 279, 521.
      Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
      Xu, H., et al. 1989. Brain Res. 504, 36.
      Product Information
      CAS number93882-12-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₁₄ClN₅O₆PS · Na
      Chemical formulaC₁₆H₁₄ClN₅O₆PS · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetProtein kinase A and protein kinase G
      Primary Target IC<sub>50</sub>900 nM against cGMP-specific phosphodiesterase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      116812

      References

      참고문헌 보기
      de Rooij, J., et al. 1998. Nature. 396, 474.
      Kawasaki, H., et al. 1998. Science. 282, 2275.
      Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
      Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
      Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
      Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
      Datta, R., et al. 1991. Blood 78, 83.
      Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
      Sandberg, M., et al. 1991. Biochem. J. 279, 521.
      Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
      Xu, H., et al. 1989. Brain Res. 504, 36.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      SynonymsAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt
      DescriptionCell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Induces the guanine-nucleotide-exchange factor activity of EGFI, also known as Epac (exchange protein directly activated by cAMP), and EGFII towards Rap1 both in vivo and in vitro. Also acts as a potent inhibitor of cGMP specific phosphodiesterase (IC50 = 900 nM). Also inhibits cAMP-specific phosphodiesterases at much higher concentrations (IC50 = 25 µM).
      FormWhite solid
      CAS number93882-12-3
      Chemical formulaC₁₆H₁₄ClN₅O₆PS · Na
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C
      Toxicity Standard Handling
      Referencesde Rooij, J., et al. 1998. Nature. 396, 474.
      Kawasaki, H., et al. 1998. Science. 282, 2275.
      Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
      Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
      Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
      Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
      Datta, R., et al. 1991. Blood 78, 83.
      Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
      Sandberg, M., et al. 1991. Biochem. J. 279, 521.
      Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
      Xu, H., et al. 1989. Brain Res. 504, 36.