116812 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem

116812
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      개요

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      주요 사양표

      Empirical FormulaCAS #
      C₁₆H₁₄ClN₅O₆PS · Na 93882-12-3

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      116812-10MGCN
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          Plastic ampoule 10 mg
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          Description
          OverviewCell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50 = 900 nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50 = 25 µM).
          Catalogue Number116812
          Brand Family Calbiochem®
          SynonymsAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt
          References
          Referencesde Rooij, J., et al. 1998. Nature. 396, 474.
          Kawasaki, H., et al. 1998. Science. 282, 2275.
          Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
          Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
          Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
          Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
          Datta, R., et al. 1991. Blood 78, 83.
          Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
          Sandberg, M., et al. 1991. Biochem. J. 279, 521.
          Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
          Xu, H., et al. 1989. Brain Res. 504, 36.
          Product Information
          CAS number93882-12-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₆H₁₄ClN₅O₆PS · Na
          Chemical formulaC₁₆H₁₄ClN₅O₆PS · Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetProtein kinase A and protein kinase G
          Primary Target IC<sub>50</sub>900 nM against cGMP-specific phosphodiesterase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          116812

          References

          참고문헌 보기
          de Rooij, J., et al. 1998. Nature. 396, 474.
          Kawasaki, H., et al. 1998. Science. 282, 2275.
          Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
          Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
          Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
          Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
          Datta, R., et al. 1991. Blood 78, 83.
          Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
          Sandberg, M., et al. 1991. Biochem. J. 279, 521.
          Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
          Xu, H., et al. 1989. Brain Res. 504, 36.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          SynonymsAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt
          DescriptionCell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Induces the guanine-nucleotide-exchange factor activity of EGFI, also known as Epac (exchange protein directly activated by cAMP), and EGFII towards Rap1 both in vivo and in vitro. Also acts as a potent inhibitor of cGMP specific phosphodiesterase (IC50 = 900 nM). Also inhibits cAMP-specific phosphodiesterases at much higher concentrations (IC50 = 25 µM).
          FormWhite solid
          CAS number93882-12-3
          Chemical formulaC₁₆H₁₄ClN₅O₆PS · Na
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (10 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C
          Toxicity Standard Handling
          Referencesde Rooij, J., et al. 1998. Nature. 396, 474.
          Kawasaki, H., et al. 1998. Science. 282, 2275.
          Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
          Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
          Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
          Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
          Datta, R., et al. 1991. Blood 78, 83.
          Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
          Sandberg, M., et al. 1991. Biochem. J. 279, 521.
          Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
          Xu, H., et al. 1989. Brain Res. 504, 36.