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203800 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem

203800
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개요

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주요 사양표

CAS #Empirical Formula
76939-46-3C₁₀H₁₀BrN₅O₆P · Na

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203800-10MGCN
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      Plastic ampoule 10 mg
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      Description
      OverviewCell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP. Preferentially activates protein kinase A (PKA). Directly activates Epac, a Rap1 guanine-nucleotide exchange factor.
      Catalogue Number203800
      Brand Family Calbiochem®
      Synonyms8-Bromo-cAMP, Na
      References
      ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
      Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.
      Product Information
      CAS number76939-46-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₀BrN₅O₆P · Na
      Chemical formulaC₁₀H₁₀BrN₅O₆P · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt, CAS 76939-46-3, is a cell-permeable cAMP analog with greater resistance to phosphodiesterases. Preferentially activates protein kinase A.
      Biological Information
      Primary TargetPKA
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid pH >8.5.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      203800

      References

      참고문헌 보기
      Kawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
      Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.

      Citations

      타이틀
    • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-May-2008 RFH
      Synonyms8-Bromo-cAMP, Na
      DescriptionCell-permeable cAMP analog that is more resistant to phosphodiesterases than cAMP. Preferentially activates cAMP-dependent protein kinase (PKA). Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII toward Rap1 both in vivo and in vitro.
      FormWhite solid
      CAS number76939-46-3
      Chemical formulaC₁₀H₁₀BrN₅O₆P · Na
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid pH >8.5.
      Toxicity Standard Handling
      ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
      Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.
      Citation
    • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.