116815 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem

116815
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH 71774-13-5

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      116815-10UMOLCN
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          Plastic ampoule 10 umol
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          Description
          OverviewA cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Raf1, both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg.
          Note: 10 µmol = 4.47 mg.
          Catalogue Number116815
          Brand Family Calbiochem®
          SynonymsAdenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
          References
          ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
          de Rooij, J., et al. 1998. Nature 396, 474.
          Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
          Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
          Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
          Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
          Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
          Product Information
          CAS number71774-13-5
          ATP CompetitiveN
          DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
          FormCrystalline solid
          Hill FormulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
          Chemical formulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetcAMP-receptor proteins
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt - CAS 71774-13-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          116815

          References

          참고문헌 보기
          Kawasaki, H., et al. 1998. Science 282, 2275.
          de Rooij, J., et al. 1998. Nature 396, 474.
          Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
          Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
          Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
          Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
          Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-October-2007 JSW
          SynonymsAdenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Sp, Sp-cAMPS, TEA
          DescriptionA cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII towards Rap1 both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg. λmax = 258 nm; εmax = 15,000 M-1cm-1 (pH 7..0).
          FormCrystalline solid
          CAS number71774-13-5
          Chemical formulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityH₂O (20 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
          de Rooij, J., et al. 1998. Nature 396, 474.
          Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
          Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28.
          Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336.
          Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292.
          Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.