182690 AhR Agonist V, VAF347 - Calbiochem

182690
가격 및 재고 조회

개요

Replacement Information

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
182690-10MGCN
재고 정보 검색...
재고 없음재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service

      Glass bottle 10 mg
      가격 검색...
      가격을 검색할 수 없습니다
      Minimum Quantity needs to be mulitiple of
      가격 문의 추가 정보
      ()이 할인됨
       
      가격 문의
      Description
      OverviewA cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
      Catalogue Number182690
      Brand Family Calbiochem®
      Synonyms(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
      References
      ReferencesPlatzer, B., et al. 2009. J. Immunol. 183, 66.
      Hauben, E., et al. 2008. Blood 118, 1214.
      Lawrence, B.P., et al. 2008. Blood 112, 1158.
      Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
      Product Information
      FormWhite solid
      Hill FormulaC₁₇H₁₁ClF₃N₃
      Chemical formulaC₁₇H₁₁ClF₃N₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AhR Agonist V, VAF347 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      AhR Agonist V, VAF347 - Calbiochem Certificates of Analysis

      TitleLot Number
      182690

      References

      참고문헌 보기
      Platzer, B., et al. 2009. J. Immunol. 183, 66.
      Hauben, E., et al. 2008. Blood 118, 1214.
      Lawrence, B.P., et al. 2008. Blood 112, 1158.
      Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-August-2012 JSW
      Synonyms(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
      DescriptionA cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₁ClF₃N₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesPlatzer, B., et al. 2009. J. Immunol. 183, 66.
      Hauben, E., et al. 2008. Blood 118, 1214.
      Lawrence, B.P., et al. 2008. Blood 112, 1158.
      Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.