Millipore Sigma Vibrant Logo

129874 Amifostine - CAS 20537-88-6 - Calbiochem

129874
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
20537-88-6C₅H₁₅N₂O₃PS •3H₂O

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
129874-50MGCN
재고 정보 검색...
재고 없음재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service

      Glass bottle 50 mg
      가격 검색...
      가격을 검색할 수 없습니다
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      가격 문의 추가 정보
      ()이 할인됨
       
      가격 문의
      Description
      OverviewA cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.
      Catalogue Number129874
      Brand Family Calbiochem®
      Synonyms2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
      References
      ReferencesDedieu, S., et al. 2010. BMC Medicine 8, 19.
      Yoon, Y.D., et al. 2005. In Vivo 19, 509.
      Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
      Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.
      Product Information
      CAS number20537-88-6
      FormOff-white solid
      Hill FormulaC₅H₁₅N₂O₃PS •3H₂O
      Chemical formulaC₅H₁₅N₂O₃PS •3H₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Amifostine - CAS 20537-88-6 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Amifostine - CAS 20537-88-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      129874

      References

      참고문헌 보기
      Dedieu, S., et al. 2010. BMC Medicine 8, 19.
      Yoon, Y.D., et al. 2005. In Vivo 19, 509.
      Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
      Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-May-2012 JSW
      Synonyms2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
      DescriptionA cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number20537-88-6
      Chemical formulaC₅H₁₅N₂O₃PS •3H₂O
      Structure formulaStructure formula
      Purity≥99% by NMR
      SolubilityH₂O
      Storage +2°C to +8°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesDedieu, S., et al. 2010. BMC Medicine 8, 19.
      Yoon, Y.D., et al. 2005. In Vivo 19, 509.
      Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
      Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.