172060 Andrographolide - CAS 5508-58-7 - Calbiochem

172060
가격을 검색할 수 없습니다
Minimum Quantity needs to be mulitiple of
가격 문의 추가 정보
()이 할인됨
 
가격 문의
재고 없음재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service
      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₂₀H₃₀O₅ 5508-58-7

      가격 및 재고여부

      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      172060-50MGCN
      재고 정보 검색...
      재고 없음재고 없음
      예상 출고 가능일 
      단종품
      제한된 수량 가능
      재고여부 확인
        Remaining: will advise
          Remaining: will advise
          추천사항
          고객 서비스로 문의
          Contact Customer Service

          Plastic ampoule 50 mg
          가격 검색...
          가격을 검색할 수 없습니다
          Minimum Quantity needs to be mulitiple of
          가격 문의 추가 정보
          ()이 할인됨
           
          가격 문의
          Description
          OverviewA bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
          Catalogue Number172060
          Brand Family Calbiochem®
          SynonymsAndro
          References
          ReferencesXia, Y.F., et al. 2004. J. Immunol. 173, 4207.
          Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
          Yu, B.C., et al. 2003. Planta Med. 69, 1075.
          Product Information
          CAS number5508-58-7
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₀H₃₀O₅
          Chemical formulaC₂₀H₃₀O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetNF-κB and AP-1 activation
          Primary Target IC<sub>50</sub>≤ 15 µM against NF-κB and AP-1 activation
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSLU3490750
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Andrographolide - CAS 5508-58-7 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Andrographolide - CAS 5508-58-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          172060

          References

          참고문헌 보기
          Xia, Y.F., et al. 2004. J. Immunol. 173, 4207.
          Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
          Yu, B.C., et al. 2003. Planta Med. 69, 1075.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-April-2008 RFH
          SynonymsAndro
          DescriptionAn irreversible blocker of NF-κB and AP-1 (IC50 ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5508-58-7
          RTECSLU3490750
          Chemical formulaC₂₀H₃₀O₅
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityDMSO (15 mg/ml) or Chloroform:Methanol (1:1) (10 mg/ml). Use only fresh DMSO.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 633
          ReferencesXia, Y.F., et al. 2004. J. Immunol. 173, 4207.
          Chen, J.H., et al. 2004. Biochem. Pharmacol. 67, 1337.
          Yu, B.C., et al. 2003. Planta Med. 69, 1075.