175580 Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem

175580
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₂H₉N₃O 186611-44-9

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      175580-10MGCN
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
          Catalogue Number175580
          Brand Family Calbiochem®
          Synonyms(Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
          References
          ReferencesBraud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243.
          Product Information
          CAS number186611-44-9
          ATP CompetitiveY
          FormYellow solid
          Hill FormulaC₁₂H₉N₃O
          Chemical formulaC₁₂H₉N₃O
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargethEGF-R tyrosine kinase activity
          Primary Target IC<sub>50</sub>54% inhibition at 10 µM against hEGF-R tyrosine kinase activity
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          175580

          References

          참고문헌 보기
          Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms(Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
          DescriptionA cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number186611-44-9
          Chemical formulaC₁₂H₉N₃O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesBraud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243.