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MABN531 Anti-Glypican-6 Antibody, clone 6A7.1

Detect Glypican using this mouse monoclonal antibody, Anti-Glypican-6 Antibody, clone 6A7.1 validated for use in western blotting & IHC.

Anti-Glypican-6 Antibody, clone 6A7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: GPC6, UNQ369/PRO705 UniProt Number: Q9Y625
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MABN531
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN531
      DescriptionAnti-Glypican-6 Antibody, clone 6A7.1
      Alternate Names
      • Glypican-6
      • Secreted glypican-6
      Background InformationThe protein named Glypican-6 and encoded by the gene GPC6, is a cell surface membrane proteoglycan protein that contains heparan sulfate residues and appears to act as a cellular receptor for various growth factors, ECM proteins, and enzymes. Moreover, Glypican-6 when over expressed enhances the migration and invasion of many cancer cells through the direct activation of the WNT5A signaling pathway. Additionally, Glypican-6 serves a developmental function as it is highly expressed in fetal tissues and defects give rises to severe dysmorphism and congenital defects. Glypican-6 is widely expressed in critical fetal tissues from kidney to brain, and in the adult high expression is seen in ovary, kidney, intestines and liver, and abundant in many cancer cells. Defects in Glypican-6 are associated with Omodysplasia 1 a rare autosomal recessive skeletal dysplasia characterized by facial dysmorphism and severe congenital micromelia giving club-like appearance to hands and feet.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Glypican using this mouse monoclonal antibody, Anti-Glypican-6 Antibody, clone 6A7.1 validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Glypican-6 in human ovarian follicles and human oviduct tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Glypican-6.
      Clone6A7.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityShould detect both pro and secreted for Glypican-6 by immunogen design
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GPC6
      • UNQ369/PRO705
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~62 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse liver tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Glypican-6 in 10 µg of mouse liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      MABN531 04053252938580