178385 Apocynin - CAS 498-02-2 - Calbiochem

178385
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      개요

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      주요 사양표

      Empirical FormulaCAS #
      C₉H₁₀O₃ 498-02-2

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      178385-1GMCN
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          Plastic ampoule 1 gm
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          Description
          OverviewA cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).
          Catalogue Number178385
          Brand Family Calbiochem®
          Synonyms4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
          References
          ReferencesAbid, M.R., et al. 2000. FEBS Lett. 486, 252.
          Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
          Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
          Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
          van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
          Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.
          Product Information
          CAS number498-02-2
          ATP CompetitiveN
          FormWhite to off-white powder
          Hill FormulaC₉H₁₀O₃
          Chemical formulaC₉H₁₀O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetNADPH oxidase
          Purity≥98% by GC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSAM8800000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Apocynin - CAS 498-02-2 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Apocynin - CAS 498-02-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          178385

          References

          참고문헌 보기
          Abid, M.R., et al. 2000. FEBS Lett. 486, 252.
          Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
          Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
          Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
          van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
          Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.

          Brochure

          Title
          Pathways and Biomarkers of Oxidative Stress
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-February-2018 JSW
          Synonyms4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
          DescriptionA cell-permeable, anti-inflammatory phenol that acts as a potent and selective inhibitor of NADPH oxidase. Also blocks peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through the activation of AP-1. Shown to prevent phagocytosis of myelin by macrophages (10 mM).
          FormWhite to off-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number498-02-2
          RTECSAM8800000
          Chemical formulaC₉H₁₀O₃
          Structure formulaStructure formula
          Purity≥98% by GC
          SolubilityDMSO (10 mg/ml) or Ethanol (20 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          Merck USA index14, 741
          ReferencesAbid, M.R., et al. 2000. FEBS Lett. 486, 252.
          Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
          Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
          Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
          van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
          Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.