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178488 Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem

178488
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개요

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주요 사양표

CAS #Empirical Formula
54135-60-3C₁₃H₁₆O₄

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178488-10MGCN
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      Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable inhibitor of apoptosis induction (IC50 = 67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells). Effects attributable to the inhibition of caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.
      Catalogue Number178488
      Brand Family Calbiochem®
      SynonymsM50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
      References
      ReferencesTsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.
      Product Information
      CAS number54135-60-3
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₃H₁₆O₄
      Chemical formulaC₁₃H₁₆O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetapoptosis induction
      Primary Target IC<sub>50</sub>67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      178488

      References

      참고문헌 보기
      Tsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-July-2009 RFH
      SynonymsM50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
      DescriptionA cell-permeable, bis(cyclohexane-1,3-diketone) that is shown to inhibit apoptosis induction in FasL-stimulated WC8 cells (IC50 = 67 µg/ml) and etoposide-stimulated U937 cells (IC50 = 130 µg/ml). The anti-apoptotic effects have been shown to be attributable to inhibition of caspase-3 activation (IC50 = 334 nM), however it does not exhibit any direct inhibition of caspase-3 enzymatic activity. Shown to inhibit the elevation of the liver enzymes, alanine aminotransferase and aspartate aminotransferase, in a murine model of anti-Fas-induced hepatitis. Topical application has been shown to reduce chemotherapy-induced alopecia (hair loss) in newborn rats.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number54135-60-3
      Chemical formulaC₁₃H₁₆O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (20 mg/ml)
      Storage +2°C to +8°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.