189410 Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem

189410
가격을 검색할 수 없습니다
Minimum Quantity needs to be mulitiple of
가격 문의 추가 정보
()이 할인됨
 
가격 문의
재고 없음재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service
      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₂₉H₃₁N₅O₄ 331771-20-1

      가격 및 재고여부

      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      189410-5MGCN
      재고 정보 검색...
      재고 없음재고 없음
      예상 출고 가능일 
      단종품
      제한된 수량 가능
      재고여부 확인
        Remaining: will advise
          Remaining: will advise
          추천사항
          고객 서비스로 문의
          Contact Customer Service

          Glass bottle 5 mg
          가격 검색...
          가격을 검색할 수 없습니다
          Minimum Quantity needs to be mulitiple of
          가격 문의 추가 정보
          ()이 할인됨
           
          가격 문의
          Description
          OverviewA cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50 = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50 = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC50 > 10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.
          Catalogue Number189410
          Brand Family Calbiochem®
          Synonyms4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline
          References
          ReferencesGadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305.
          Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.
          Product Information
          CAS number331771-20-1
          FormWhite solid
          Hill FormulaC₂₉H₃₁N₅O₄
          Chemical formulaC₂₉H₃₁N₅O₄
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          189410

          References

          참고문헌 보기
          Gadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305.
          Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2018 JSW
          Synonyms4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline
          DescriptionA cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50 = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50 = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC50 > 10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number331771-20-1
          Chemical formulaC₂₉H₃₁N₅O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Regulatory Review
          ReferencesGadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305.
          Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.