189480 Autocamtide-2 Related Inhibitory Peptide - Calbiochem

189480
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      개요

      Replacement Information

      주요 사양표

      Empirical Formula
      C₆₄H₁₁₆N₂₂O₁₉

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      189480-500UGCN
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          Plastic ampoule 500 μg
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          Description
          OverviewNon-phosphorylatable analog of Autocamtide-2 (Cat. No. 189475) that acts as a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM). It is about 50 times more potent than [Ala286]-CaM kinase II Inhibitor, 281-301 (Cat. No. 208710). Has no effect on PKA, PKC, and CaM kinase IV. Blocks Ca2+-induced insulin secretion from electropermeabilized islets.
          Catalogue Number189480
          Brand Family Calbiochem®
          SynonymsAIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
          References
          ReferencesBhat, H.S., et al. 2000. Biochem. Pharmacol. 60, 1655.
          Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun. 212, 806.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₆₄H₁₁₆N₂₂O₁₉
          Chemical formulaC₆₄H₁₁₆N₂₂O₁₉
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCam Kinase-2
          Primary Target IC<sub>50</sub>40 nM against calmodulin-dependent protein kinase II
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Autocamtide-2 Related Inhibitory Peptide - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Autocamtide-2 Related Inhibitory Peptide - Calbiochem Certificates of Analysis

          TitleLot Number
          189480

          References

          참고문헌 보기
          Bhat, H.S., et al. 2000. Biochem. Pharmacol. 60, 1655.
          Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun. 212, 806.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2008 RFH
          SynonymsAIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
          DescriptionNon-phosphorylatable analog of Autocamptide-2 (Cat. No. 189475) that is a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM) and is 50 and 500 times more potent than Ala286-CaM kinase II inhibitor, 281-301 (Cat. No. 208710) and KN-93 (Cat. No. 422708), respectively. Has no effect of PKA, PKC, and CaM kinase IV.
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₆₄H₁₁₆N₂₂O₁₉
          Peptide SequenceH-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
          Purity≥97% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBhat, H.S., et al. 2000. Biochem. Pharmacol. 60, 1655.
          Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun. 212, 806.