189497 Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem

189497
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₅H₁₃N₃S 315702-99-9

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      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      189497-10MGCN
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
          Catalogue Number189497
          Brand Family Calbiochem®
          SynonymsN-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
          References
          ReferencesTurcotte, S., et al. 2008. Cancer Cell 14, 90.
          Product Information
          CAS number315702-99-9
          FormBeige solid
          Hill FormulaC₁₅H₁₃N₃S
          Chemical formulaC₁₅H₁₃N₃S
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22-41

          Harmful if swallowed.
          Risk of serious damage to eyes.
          S PhraseS: 26-39

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          189497

          References

          참고문헌 보기
          Turcotte, S., et al. 2008. Cancer Cell 14, 90.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-August-2009 RFH
          SynonymsN-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
          DescriptionA cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
          FormBeige solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number315702-99-9
          Chemical formulaC₁₅H₁₃N₃S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Toxic
          ReferencesTurcotte, S., et al. 2008. Cancer Cell 14, 90.