189510 Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem

189510
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Empirical FormulaCAS #
C₂₁H₃₄NO₄PNa₂ • 2H₂O 1103672-43-0

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189510-5MGCN
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      Glass bottle 5 mg
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      Description
      OverviewA phosphonate compound that potently inhibits both the phosphodiesterase (IC50 = 9 nM in pNppp assay using ATX β) and the lysoPLD (IC50 = 5.6 nM and 47 nM, by enzyme-linked fluorescence detection or autoradiography by TLC, respectively, using ATX β) activities of ATX α/β/γ, while exhibiting much reduced (IC50 ~ 6 µM and 15 µM against Src and PTP-1B, respectively) or little activity toward 29 other receptors and enzymes. Shown to block LPA release from murine 3T3F422A adipocytes (IC50 = 90 nM) in vitro and from excised human and rat adipose tissues (by ~70% inhibition at 0.2 and 1 µM, respectively) in cultures ex vivo. The in vivo applicability of S32826 is limited by its low epithelial permeability and other poor pharmacokinetic properties. CTAB (Cat. No. 219374) is reported to counteract the inhibitory activity of S32826, 2-methyl-2,4-pentanediol can be used instead to stabilize purified enzyme in solution during S32826 inhibition assays.
      Catalogue Number189510
      Brand Family Calbiochem®
      SynonymsATX Inhibitor I, (4-(Tetradecanoylamino)benzyl)phosphonic acid disodium, dihydrate
      References
      ReferencesBoutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
      Samadi, N., et al. 2009. Oncogene 28, 1028.
      Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.
      Product Information
      CAS number1103672-43-0
      FormWhite powder
      Hill FormulaC₂₁H₃₄NO₄PNa₂ • 2H₂O
      Chemical formulaC₂₁H₃₄NO₄PNa₂ • 2H₂O
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      189510

      References

      참고문헌 보기
      Boutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
      Samadi, N., et al. 2009. Oncogene 28, 1028.
      Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-March-2011 RFH
      SynonymsATX Inhibitor I, (4-(Tetradecanoylamino)benzyl)phosphonic acid disodium, dihydrate
      DescriptionA phosphonate compound that potently inhibits both the phosphodiesterase (IC50 = 9 nM in pNppp assay using ATX β) and the lysoPLD (IC50 = 5.6 nM and 47 nM, by enzyme-linked fluorescence detection or autoradiography by TLC, respectively, using ATX β) activities of ATX α/β/γ, while exhibiting much reduced (IC50 ~6 µM and 15 µM against Src and PTP-1B, respectively) or little activity toward 29 other receptors and enzymes. Shown to block LPA release from murine 3T3F422A adipocytes (IC50 = 90 nM) in vitro and from excised human and rat adipose tissues (by ~70% inhibition at 0.2 and 1 µM, respectively) in cultures ex vivo. The in vivo applicability of S32826 is limited by its low epithelial permeability and other poor pharmacokinetic properties. CTAB (Cat. No. 219374) is reported to counteract the inhibitory activity of S32826, 2-methyl-2,4-pentanediol can be used instead to stabilize purified enzyme in solution during S32826 inhibition assays.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1103672-43-0
      Chemical formulaC₂₁H₃₄NO₄PNa₂ • 2H₂O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (0.5 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesBoutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
      Samadi, N., et al. 2009. Oncogene 28, 1028.
      Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.