196870 BAY 11-7082 - CAS 19542-67-7 - Calbiochem

196870
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₀H₉NO₂S 19542-67-7

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      196870-10MGCN
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          Glass bottle 10 mg
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          Description
          OverviewPotential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC50 = 10 µM), resulting in a decreased expression of NF-κB and of adhesion molecules. Does not affect constitutive IκBα autophosphorylation. Inhibits TNF-α-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. A 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196871) in DMSO is also available is also available.
          Catalogue Number196870
          Brand Family Calbiochem®
          Synonyms(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
          References
          ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
          Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
          Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
          Product Information
          CAS number19542-67-7
          FormOff-white solid
          Hill FormulaC₁₀H₉NO₂S
          Chemical formulaC₁₀H₉NO₂S
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationBAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules.
          Biological Information
          Primary TargetTNF-α-inducible phosphorylation of IκBα
          Primary Target IC<sub>50</sub>10 µM inhibiting TNF-α-inducible phosphorylation of IκBα
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          BAY 11-7082 - CAS 19542-67-7 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          BAY 11-7082 - CAS 19542-67-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          196870

          References

          참고문헌 보기
          Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
          Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
          Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

          Brochure

          Title
          Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

          Citations

          타이틀
        • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
        • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
        • Meng-Hsing Wu, et al. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. 90, 286-295.
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2010 RFH
          Synonyms(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
          DescriptionPotential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50 = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number19542-67-7
          Chemical formulaC₁₀H₉NO₂S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
          Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
          Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
          Citation
        • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
        • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
        • Meng-Hsing Wu, et al. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. 90, 286-295.
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.