203895 BTS - CAS 1576-37-0 - Calbiochem

203895
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₄H₁₅NO₂S 1576-37-0

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      203895-5MGCN
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          Plastic ampoule 5 mg
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          Description
          OverviewA potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.
          Catalogue Number203895
          Brand Family Calbiochem®
          SynonymsN-Benzyl-p-toluenesulphonamide
          References
          ReferencesCheung, A., et al. 2002. Nat. Cell Biol. 4, 83.
          Product Information
          CAS number1576-37-0
          ATP CompetitiveN
          FormWhite crystalline solid
          Hill FormulaC₁₄H₁₅NO₂S
          Chemical formulaC₁₄H₁₅NO₂S
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCa2+-stimulated myosin S1 ATPase
          Primary Target IC<sub>50</sub>~5 µM against Ca2+-stimulated myosin S1 ATPase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSXT5490000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          BTS - CAS 1576-37-0 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          BTS - CAS 1576-37-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          203895

          References

          참고문헌 보기
          Cheung, A., et al. 2002. Nat. Cell Biol. 4, 83.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-May-2008 RFH
          SynonymsN-Benzyl-p-toluenesulphonamide
          DescriptionAn aryl sulphonamide that acts as a potent inhibitor of Ca2+-stimulated myosin S1 actin-stimulated ATPase activity (IC50 = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC50 = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC50 < 2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.
          FormWhite crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1576-37-0
          RTECSXT5490000
          Chemical formulaC₁₄H₁₅NO₂S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesCheung, A., et al. 2002. Nat. Cell Biol. 4, 83.