196000 Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem

196000
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₃₅H₅₈O₉ 88899-55-2

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      196000-10UGCN
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          Plastic ampoule 10 μg
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          196000-1SETCN
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              Glass bottle 1 set
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              Description
              OverviewA macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution™ format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).
              Note: 1 set = 3 x 10 µg
              Catalogue Number196000
              Brand Family Calbiochem®
              References
              ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
              Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
              Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
              Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
              Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
              Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
              Drose, S., et al. 1993. Biochemistry 32, 3902.
              Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
              Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.
              Product Information
              CAS number88899-55-2
              FormWhite solid
              Hill FormulaC₃₅H₅₈O₉
              Chemical formulaC₃₅H₅₈O₉
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary Targetvacuolar type H+ ATPase
              Primary Target IC<sub>50</sub>500 pM
              Purity≥90% by HPLC
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 36/37/38

              Irritating to eyes, respiratory system and skin.
              S PhraseS: 22-26-36

              Do not breathe dust.
              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Carcinogenic / Teratogenic
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem MSDS

              타이틀

              물질안전보건자료(MSDS) 

              Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem Certificates of Analysis

              TitleLot Number
              196000

              References

              참고문헌 보기
              Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
              Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
              Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
              Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
              Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
              Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
              Drose, S., et al. 1993. Biochemistry 32, 3902.
              Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
              Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

              Brochure

              Title
              Caspases and other Apoptosis Related Tools Brochure
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision23-February-2010 JSW
              DescriptionA macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 0.5 nM) and is a valuable tool for distinguishing among different types of ATPases. Reported to selectivity inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). Blocks lysosomal cholesterol trafficking in macrophages. Known to interfere with pH regulation in brain cells. Inhibits bone resorption both in vivo and in vitro. Has been shown to exhibit cytotoxic effects on a number of cell lines in a cell viability assay.
              FormWhite solid
              CAS number88899-55-2
              Chemical formulaC₃₅H₅₈O₉
              Structure formulaStructure formula
              Purity≥90% by HPLC
              SolubilityDMSO (100 µM) or Ethanol
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.
              Toxicity Carcinogenic / Teratogenic
              ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
              Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
              Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
              Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
              Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
              Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
              Drose, S., et al. 1993. Biochemistry 32, 3902.
              Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
              Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.