196322 Baicalein - CAS 491-67-8 - Calbiochem

196322
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      가격 및 재고 조회

      개요

      Replacement Information

      가격 및 재고여부

      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      196322-10MGCN
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C.
          Catalogue Number196322
          Brand Family Calbiochem®
          Synonyms5,6,7-Trihydroxyflavone
          References
          ReferencesLeabeau, A., et al. 2001. Neuroreport 12, 2199.
          Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
          Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
          Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
          Butenko, I.G., et al. 1993. Agents Actions 39, C49.
          Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
          Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
          Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.
          Product Information
          CAS number491-67-8
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₅H₁₀O₅
          Chemical formulaC₁₅H₁₀O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Target12-lipoxygenase
          Primary Target IC<sub>50</sub>120 nM against 12-lipoxygenase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Baicalein - CAS 491-67-8 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Baicalein - CAS 491-67-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          196322

          References

          참고문헌 보기
          Leabeau, A., et al. 2001. Neuroreport 12, 2199.
          Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
          Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
          Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
          Butenko, I.G., et al. 1993. Agents Actions 39, C49.
          Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
          Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
          Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-August-2018 JSW
          Synonyms5,6,7-Trihydroxyflavone
          DescriptionA cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Reduces leukotriene biosynthesis and the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induces arthritis. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated PKC.
          FormYellow solid
          CAS number491-67-8
          Chemical formulaC₁₅H₁₀O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (20 mg/ml) or Acetone
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Irritant
          Merck USA index14, 942
          ReferencesLeabeau, A., et al. 2001. Neuroreport 12, 2199.
          Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
          Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
          Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
          Butenko, I.G., et al. 1993. Agents Actions 39, C49.
          Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
          Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
          Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.