203734 Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem

203734
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₅₀H₇₂O₁₄ 85079-48-7

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      203734-100UGCN
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          Alu drum 100 μg
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          Description
          OverviewLipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.
          Catalogue Number203734
          Brand Family Calbiochem®
          SynonymsPumiliotoxin, Dihydrobrevetoxin B
          References
          ReferencesBaden, D.G., et al. 1994. Nat. Toxins 2, 212.
          Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
          Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
          Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
          Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
          Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
          Baden, D.G., et al. 1988. Toxicon 26, 97.
          Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
          Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
          Baden, D.G., et al. 1982. Toxicon 19, 455.
          Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
          Product Information
          CAS number85079-48-7
          ATP CompetitiveN
          FormSolid
          Hill FormulaC₅₀H₇₂O₁₄
          Chemical formulaC₅₀H₇₂O₁₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationBrevetoxin PbTx-3, Ptychodiscus brevis, CAS 85079-48-7, is a lipid-soluble polyether marine toxin that acts as a voltage-dependent Na+ channel activator. Causes contractile paralysis in animal models.
          Biological Information
          Primary TargetVoltage-dependent Na+ channel activator
          Purity>95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSXW5885000
          Safety Information
          R PhraseR: 26/27/28

          Very toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use teflon or silicon pipette tips.
          End use certificateY
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          203734

          References

          참고문헌 보기
          Baden, D.G., et al. 1994. Nat. Toxins 2, 212.
          Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
          Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
          Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
          Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
          Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
          Baden, D.G., et al. 1988. Toxicon 26, 97.
          Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
          Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
          Baden, D.G., et al. 1982. Toxicon 19, 455.
          Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-September-2010 JSW
          SynonymsPumiliotoxin, Dihydrobrevetoxin B
          DescriptionLipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number85079-48-7
          RTECSXW5885000
          Chemical formulaC₅₀H₇₂O₁₄
          Structure formulaStructure formula
          Purity>95% by HPLC
          SolubilityDMSO (30 mg/ml), Methanol (30 mg/ml), Acetonitrile(30 mg/ml), Chloroform (30 mg/ml), Ethanol (10 mg/ml). Only sparingly soluble in H₂O
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use teflon or silicon pipette tips.
          Toxicity Highly Toxic
          ReferencesBaden, D.G., et al. 1994. Nat. Toxins 2, 212.
          Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
          Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
          Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
          Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
          Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
          Baden, D.G., et al. 1988. Toxicon 26, 97.
          Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
          Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
          Baden, D.G., et al. 1982. Toxicon 19, 455.
          Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.

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          카테고리

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Channel Openers