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203988 Butyrolactone I - CAS 87414-49-1 - Calbiochem

203988
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
87414-49-1C₂₄H₂₄O₇

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
203988-200UGCN
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      Plastic ampoule 200 μg
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      Description
      OverviewA cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G1/S and G2/M transitions. Inhibits p34cdk1/cyclinB (Cdk1; IC50 = 680 nM). Also selectively inhibits Cdk2 and Cdk5 kinases. Has little effect on casein kinase I, casein kinase II, EGF receptor kinase, MAP kinase, PKA, and PKC. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Also blocks Fas-induced apoptosis in HL-60 cells and shows antitumor effects on human lung cancer cell lines.
      Catalogue Number203988
      Brand Family Calbiochem®
      References
      ReferencesFurukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.
      Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
      Kitagawa, M., et al. 1994. Oncogene 9, 2549.
      Kitagawa, M., et al. 1993. Oncogene 8, 2425.
      Product Information
      CAS number87414-49-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₄H₂₄O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp34cdk1/cyclinB
      Primary Target IC<sub>50</sub>680 nM against Cdk1
      Purity≥99% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Butyrolactone I - CAS 87414-49-1 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Butyrolactone I - CAS 87414-49-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      203988

      References

      참고문헌 보기
      Furukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.
      Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
      Kitagawa, M., et al. 1994. Oncogene 9, 2549.
      Kitagawa, M., et al. 1993. Oncogene 8, 2425.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      DescriptionA cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G1/S and G2/M transitions. Inhibits p34cdk1/cyclinB (Cdk1; IC50 = 680 nM). Also selectively inhibits Cdk2 and Cdk5 kinases. Has little effect on casein kinase I, casein kinase II, EGF receptor kinase, MAP kinase, PKA, and PKC. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Also blocks Fas-induced apoptosis in HL-60 cells and shows antitumor effects on human lung cancer cell lines.
      FormWhite solid
      CAS number87414-49-1
      Structure formulaStructure formula
      Purity≥99% by TLC
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesFurukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.
      Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
      Kitagawa, M., et al. 1994. Oncogene 9, 2549.
      Kitagawa, M., et al. 1993. Oncogene 8, 2425.