234415 C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem

234415
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      개요

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      Empirical FormulaCAS #
      C₃₀H₃₆N₂O₂ • HCl 405098-33-1

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      234415-1MGCN
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          Plastic ampoule 1 mg
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          234415-5MGCN
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              Plastic ampoule 5 mg
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              Description
              OverviewA tetrahydronaphthalenyl carboxamide compound that acts as a potent, specific and orally active C5a receptor antagonist. Shown to inhibit the binding of 125I-rhC5a to human neutrophils with a Ki of 2.2 nM, as well as C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation (IC50 = 3.1 nM, 2.7 nM and 1.6 nM, respectively) with no agonist activity up to 10 µM. Shown to prevent C5a-induced neutrophenia in gerbils (100 µg/kg i.v. or 3-30 mg/kg orally).
              Catalogue Number234415
              Brand Family Calbiochem®
              SynonymsN-((4-Dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide, HCl
              References
              ReferencesSumichika, H., et al. 2002. J. Biol. Chem. 277, 49403.
              Product Information
              CAS number405098-33-1
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₃₀H₃₆N₂O₂ • HCl
              Chemical formulaC₃₀H₃₆N₂O₂ • HCl
              Hygroscopic Hygroscopic
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetC5a Receptor
              Primary Target IC<sub>50</sub>3.1 nM, 2.7 nM and 1.6 nM against C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation, respectively
              Primary Target K<sub>i</sub>2.2 nM against the binding of 125I-rhC5a to human neutrophils
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem MSDS

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              물질안전보건자료(MSDS) 

              C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem Certificates of Analysis

              TitleLot Number
              234415

              References

              참고문헌 보기
              Sumichika, H., et al. 2002. J. Biol. Chem. 277, 49403.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision09-June-2008 RFH
              SynonymsN-((4-Dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide, HCl
              DescriptionA potent, specific, and orally active C5a receptor antagonist. Shown to inhibit the binding of 125I-rhC5a to human neutrophils with a Ki of 2.2 nM, as well as C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation (IC50 = 3.1 nM, 2.7 nM and 1.6 nM, respectively) with no agonist activity up to 10 µM. Shown to prevent C5a-induced neutrophenia in gerbils (100 µg/kg i.v. or 3-30 mg/kg orally).
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number405098-33-1
              Chemical formulaC₃₀H₃₆N₂O₂ • HCl
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (50 mg/ml) or Methanol (50 mg/ml)
              Storage +2°C to +8°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesSumichika, H., et al. 2002. J. Biol. Chem. 277, 49403.