205531 CA-074 Me - Calbiochem

205531
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical Formula
      C₁₉H₃₁N₃O₆

      가격 및 재고여부

      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      205531-1MGCN
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
          Catalogue Number205531
          Brand Family Calbiochem®
          SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
          References
          ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
          Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
          Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
          Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₉H₃₁N₃O₆
          Chemical formulaC₁₉H₃₁N₃O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetcathepsin B
          Primary Target IC<sub>50</sub>2.24 nM against cathepsin B
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          CA-074 Me - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          CA-074 Me - Calbiochem Certificates of Analysis

          TitleLot Number
          205531

          References

          참고문헌 보기
          Sever, N., et al. 2002. Biol. Chem. 383, 839.
          Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
          Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
          Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.

          Citations

          타이틀
          IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-May-2008 RFH
          SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
          DescriptionA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B.
          FormWhite solid
          Chemical formulaC₁₉H₃₁N₃O₆
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
          Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
          Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
          Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
          CitationIM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.