236015 COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem

236015
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₅H₁₃F₂NO₄S 116686-15-8

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      236015-5MGCN
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.
          Catalogue Number236015
          Brand Family Calbiochem®
          Synonyms4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
          References
          ReferencesOtani, Y., et al. 2007. J. Invest. Surg. 20, 175.
          Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
          Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
          Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
          Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.
          Product Information
          CAS number116686-15-8
          FormWhite solid
          Hill FormulaC₁₅H₁₃F₂NO₄S
          Chemical formulaC₁₅H₁₃F₂NO₄S
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-36/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          236015

          References

          참고문헌 보기
          Otani, Y., et al. 2007. J. Invest. Surg. 20, 175.
          Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
          Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
          Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
          Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-March-2009 RFH
          Synonyms4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
          DescriptionA cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number116686-15-8
          Chemical formulaC₁₅H₁₃F₂NO₄S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (30 mg/ml) or Ethanol (15 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesOtani, Y., et al. 2007. J. Invest. Surg. 20, 175.
          Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
          Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
          Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
          Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.