239824 CXCR7 Agonist, VUF11207 - Calbiochem

239824
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개요

Replacement Information

주요 사양표

Empirical Formula
C₂₇H₃₅FN₂O₄

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239824-10MGCN
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      Glass bottle 10 mg
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      Description
      OverviewA styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.
      Catalogue Number239824
      Brand Family Calbiochem®
      SynonymsRDC-1 Agonist, GPR159 Agonist, (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist
      References
      ReferencesWijtmans, M., et al. 2011, Eur J Med Chem 51, 184.
      Product Information
      FormLight yellow oil
      Hill FormulaC₂₇H₃₅FN₂O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCXCR7 Agonist, VUF11207, CAS 1378524-41-4, is a high affinity and high potency ligand of CXCR7 (pKi = 8.1). Induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7.
      Biological Information
      Primary TargetCXCR7
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      CXCR7 Agonist, VUF11207 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      CXCR7 Agonist, VUF11207 - Calbiochem Certificates of Analysis

      TitleLot Number
      239824

      References

      참고문헌 보기
      Wijtmans, M., et al. 2011, Eur J Med Chem 51, 184.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-June-2020 JSW
      SynonymsRDC-1 Agonist, GPR159 Agonist, (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist
      DescriptionA styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.
      FormLight yellow oil
      Intert gas (Yes/No) Packaged under inert gas
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWijtmans, M., et al. 2011, Eur J Med Chem 51, 184.