205546 Caffeic Acid - CAS 331-39-5 - Calbiochem

205546
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₉H₈O₄ 331-39-5

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      205546-500MGCN
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          Plastic ampoule 500 mg
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          Description
          OverviewA natural dietary compound reported to have anti-carcinogenic and anti-inflammatory properties. A cell-permeable, selective, non-competitive inhibitor of 5-lipoxygenase (ID50 = 3.7 µM). Inhibits Cu2+-induced LDL oxidation in the initiation phase but acts as a prooxidant in the propagation phase. An irreversible inhibitor of glutathione S-transferases and a non-competitive inhibitor of xanthine oxidase.
          Catalogue Number205546
          Brand Family Calbiochem®
          Synonyms3,4-Dihydroxycinnamic Acid
          References
          ReferencesYamanaka, N., et al. 1997. FEBS Lett. 405, 186.
          Chan, W.S., et al. 1995. Anticancer Res. 15, 703.
          Ploemen, J.H., et al. 1993. Food Chem. Toxicol. 31, 475.
          Koshihara, Y., et al. 1984. Biochim. Biophys. Acta 792, 92.
          Product Information
          CAS number331-39-5
          ATP CompetitiveN
          FormTan crystalline solid
          Hill FormulaC₉H₈O₄
          Chemical formulaC₉H₈O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Target5-lipoxygenase
          Primary Target IC<sub>50</sub>3.7 µM against 5-lipoxygenase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGD8950000
          Safety Information
          R PhraseR: 40

          Limited evidence of a carcinogenic effect.
          S PhraseS: 36/37

          Wear suitable protective clothing and gloves.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Caffeic Acid - CAS 331-39-5 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Caffeic Acid - CAS 331-39-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          205546

          References

          참고문헌 보기
          Yamanaka, N., et al. 1997. FEBS Lett. 405, 186.
          Chan, W.S., et al. 1995. Anticancer Res. 15, 703.
          Ploemen, J.H., et al. 1993. Food Chem. Toxicol. 31, 475.
          Koshihara, Y., et al. 1984. Biochim. Biophys. Acta 792, 92.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          Synonyms3,4-Dihydroxycinnamic Acid
          DescriptionA cell-permeable natural dietary compound reported to have anti-carcinogenic and anti-inflammatory properties. A selective, non-competitive inhibitor of 5-lipoxygenase (ID50 = 3.7 µM). Inhibits Cu2+-induced LDL oxidation in the initiation phase but acts as a prooxidant in the propagation phase. An effective irreversible inhibitor of glutathione S-transferases and a non-competitive inhibitor of xanthine oxidase.
          FormTan crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number331-39-5
          RTECSGD8950000
          Chemical formulaC₉H₈O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml) or Ethanol (50 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 1635
          ReferencesYamanaka, N., et al. 1997. FEBS Lett. 405, 186.
          Chan, W.S., et al. 1995. Anticancer Res. 15, 703.
          Ploemen, J.H., et al. 1993. Food Chem. Toxicol. 31, 475.
          Koshihara, Y., et al. 1984. Biochim. Biophys. Acta 792, 92.